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Filling in genomic blanks for disease studies works better for some groups than others

Filling in genomic blanks for disease studies works better for some groups than others
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

New Zealand , United States , Papua New Guinea , Saudi Arabia , Republic Of , Charleston Chiang , Minhui Chen , Xinyue Rui , Jalen Langie , Christopher Simons , Keck School Of Medicine Center , Keck School Of Medicine , Viterbi School Of Engineering , Dornsife College , Norris Comprehensive Cancer Center , Keck School , American Journal , Human Genetics , African Americans , Pacific Islands , Comprehensive Cancer , Jordan Cahoon , Echo Tang ,

Researchers find genetic variant contributing to disparities in childhood leukemia risk

Researchers find genetic variant contributing to disparities in childhood leukemia risk
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

United States , Vijay Sankaran , Charleston Chiang , Keck School Of Medicine , Blood Disorders Center , Harvard Medical School , Leukemia Lymphoma Society , Norris Comprehensive Cancer Center , Keck School , Adam De Smith , Comprehensive Cancer Center , Genetic Epidemiology , California Cancer Records Linkage , Indigenous American , Boston Children ,

USC researchers find genetic variant contribu

<p style="text-align:start">Children of Hispanic/Latino origin are 30-40% more likely to get Acute lymphoblastic leukemia (ALL) than non-Hispanic white children. However, the exact genetic basis and cause of that increased risk are unknown. Now researchers have revealed a key genetic variant contributing towards the increased risk, as well as details about the biological basis of ALL.&nbsp;The research team focused on the&nbsp;<em>IKZF1&nbsp;</em>gene, known to relate to ALL but never before linked with ethnic risk disparities. Using genetic fine-mapping analysis, they independently analyzed each position along the gene&mdash;known as a single nucleotide polymorphism (SNP)&mdash;to determine whether having a certain variant increased ALL risk. They found three independent SNPs linked to higher ALL incidence, one of which was present in about 30% of people of Hispanic/Latino origin in the U.S. and less than 1%&nbsp;&nbsp;of people ....

New York , United States , Dana Farber Cancer Institute , Jun Yang , Stanford University , San Francisco , Soyoung Jeon , Tsz Fung Chan , Catherine Metayer , Soumyaa Mazumder , Xiaomei Ma , Esteban Gonzalez Burchard , Guangze Xia , Steven Gazal , Joseph Wiemels , Vijay Sankaran , Nathan Nakatsuka , Nicholas Mancuso , Elad Ziv , Lara Wahlster , Celeste Eng , Wenjian Yang , Charleston Chiang , Jalen Langie , Linda Kachuri , Fulong Yu ,