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Study Finds ALL Genetic Variant That Indicates Why Hispanic, Pediatric Patients Are Likely to Develop Disease

Pediatric patients with the variant were approximately 1.44 times more likely develop ALL compared with children who do not have the variant. ....

Charleston Chiang , Leukemia Lymphoma Society , Keck School Of Medicine , Norris Comprehensive Cancer Center , Keck School , Southern California , Hispanic White , Genetic Epidemiology , East Asian , Adam De Smith , Comprehensive Cancer Center , Lymphoma Society ,

Researchers find genetic variant contributing to disparities in childhood leukemia risk

Researchers find genetic variant contributing to disparities in childhood leukemia risk
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United States , Vijay Sankaran , Charleston Chiang , Keck School Of Medicine , Blood Disorders Center , Harvard Medical School , Leukemia Lymphoma Society , Norris Comprehensive Cancer Center , Keck School , Adam De Smith , Comprehensive Cancer Center , Genetic Epidemiology , California Cancer Records Linkage , Indigenous American , Boston Children ,

USC researchers find genetic variant contribu

<p style="text-align:start">Children of Hispanic/Latino origin are 30-40% more likely to get Acute lymphoblastic leukemia (ALL) than non-Hispanic white children. However, the exact genetic basis and cause of that increased risk are unknown. Now researchers have revealed a key genetic variant contributing towards the increased risk, as well as details about the biological basis of ALL. The research team focused on the <em>IKZF1 </em>gene, known to relate to ALL but never before linked with ethnic risk disparities. Using genetic fine-mapping analysis, they independently analyzed each position along the gene—known as a single nucleotide polymorphism (SNP)—to determine whether having a certain variant increased ALL risk. They found three independent SNPs linked to higher ALL incidence, one of which was present in about 30% of people of Hispanic/Latino origin in the U.S. and less than 1%  of people ....

New York , United States , Dana Farber Cancer Institute , Jun Yang , Stanford University , San Francisco , Soyoung Jeon , Tsz Fung Chan , Catherine Metayer , Soumyaa Mazumder , Xiaomei Ma , Esteban Gonzalez Burchard , Guangze Xia , Steven Gazal , Joseph Wiemels , Vijay Sankaran , Nathan Nakatsuka , Nicholas Mancuso , Elad Ziv , Lara Wahlster , Celeste Eng , Wenjian Yang , Charleston Chiang , Jalen Langie , Linda Kachuri , Fulong Yu ,

Unraveling Genetic Variant's Role in Childhood Leukemia Risk

The IKZF1 gene variant sheds light on the increased risk of acute lymphoblastic leukemia in Hispanic/Latino children. ....

United States , Charleston Chiang , Vijay Sankaran , Keck School Of Medicine , Leukemia Lymphoma Society , Blood Disorders Center , Harvard Medical School , Norris Comprehensive Cancer Center , National Institutes Of Health , Keck School , Acute Lymphoblastic Leukemia , National Institutes , Adam De Smith , Comprehensive Cancer Center , Genetic Epidemiology , California Cancer Records Linkage , Indigenous American , Boston Children , Blood Cancer ,

Study reveals genetic variant linked to increased risk of leukemia in Hispanic/Latino children

Acute lymphoblastic leukemia (ALL), the most common childhood cancer, disproportionately affects children of Hispanic/Latino origin in the United States. ....

San Francisco , United States , Stanford University , Dana Farber Cancer Institute , Jun Yang , New York , Charleston Chiang , Lara Wahlster , Xiaomei Ma , Nathan Nakatsuka , Jalen Langie , Nicholas Mancuso , Celeste Eng , Tsz Fung Chan , Vijay Sankaran , Catherine Metayer , Steven Gazal , Elad Ziv , Esteban Gonzalez Burchard , Soyoung Jeon , Soumyaa Mazumder , Guangze Xia , Fulong Yu , Linda Kachuri , Wenjian Yang , Joseph Wiemels ,