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Ancient DNA reveals origin of racial/ethnic d

<p>Hispanic/Latino individuals have the highest risk of acute lymphoblastic leukemia (ALL) in the United States.  However, the basis for this difference is not well understood. Researchers recently identified a genetic variant that accounts for the increased risk of B-cell ALL in Hispanic/Latino children, and using ancient DNA, they traced the mutation all the way back to the first migrants who entered the Americas ~13,000 years ago. The findings were published in <em>Cell Genomics</em> on March 26.</p>
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United States , New York , Lara Wahlster , Vijay Sankaran , University Of Southern California , York Stem Cell Foundation , Broad Institute , Dana Farber Cancer Institute Presidential Priorities Initiative , Blood Disorders Center , Leukemia Lymphoma Society , National Institutes Of Health , Boston Children , Blood Disorders , Cell Genomics , Associate Member , Indigenous American , Latin America , National Institutes , New York Stem Cell Foundation , Lymphoma Society ,

USC researchers find genetic variant contribu

<p style="text-align:start">Children of Hispanic/Latino origin are 30-40% more likely to get Acute lymphoblastic leukemia (ALL) than non-Hispanic white children. However, the exact genetic basis and cause of that increased risk are unknown. Now researchers have revealed a key genetic variant contributing towards the increased risk, as well as details about the biological basis of ALL. The research team focused on the <em>IKZF1 </em>gene, known to relate to ALL but never before linked with ethnic risk disparities. Using genetic fine-mapping analysis, they independently analyzed each position along the gene—known as a single nucleotide polymorphism (SNP)—to determine whether having a certain variant increased ALL risk. They found three independent SNPs linked to higher ALL incidence, one of which was present in about 30% of people of Hispanic/Latino origin in the U.S. and less than 1%  of people ....

New York , United States , Dana Farber Cancer Institute , Jun Yang , Stanford University , San Francisco , Soyoung Jeon , Tsz Fung Chan , Catherine Metayer , Soumyaa Mazumder , Xiaomei Ma , Esteban Gonzalez Burchard , Guangze Xia , Steven Gazal , Joseph Wiemels , Vijay Sankaran , Nathan Nakatsuka , Nicholas Mancuso , Elad Ziv , Lara Wahlster , Celeste Eng , Wenjian Yang , Charleston Chiang , Jalen Langie , Linda Kachuri , Fulong Yu ,

Study reveals genetic variant linked to increased risk of leukemia in Hispanic/Latino children

Acute lymphoblastic leukemia (ALL), the most common childhood cancer, disproportionately affects children of Hispanic/Latino origin in the United States. ....

San Francisco , United States , Stanford University , Dana Farber Cancer Institute , Jun Yang , New York , Charleston Chiang , Lara Wahlster , Xiaomei Ma , Nathan Nakatsuka , Jalen Langie , Nicholas Mancuso , Celeste Eng , Tsz Fung Chan , Vijay Sankaran , Catherine Metayer , Steven Gazal , Elad Ziv , Esteban Gonzalez Burchard , Soyoung Jeon , Soumyaa Mazumder , Guangze Xia , Fulong Yu , Linda Kachuri , Wenjian Yang , Joseph Wiemels ,

Ancient DNA Unveils Racial Disparity Roots in Child Cancer

Ancient DNA Unveils Racial Disparity Roots in Child Cancer
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New York , United States , Lara Wahlster , Vijay Sankaran , Blood Disorders Center , Broad Institute , University Of Southern California , Leukemia Lymphoma Society , York Stem Cell Foundation , Dana Farber Cancer Institute Presidential Priorities Initiative , National Institutes Of Health , Boston Children , Blood Disorders , Cell Genomics , Associate Member , Indigenous American , Latin America , National Institutes , New York Stem Cell Foundation , Lymphoma Society ,

Ancient DNA reveals origin of racial/ethnic d

Ancient DNA reveals origin of racial/ethnic d
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

United States , New York , Vijay Sankaran , Lara Wahlster , Dana Farber Cancer Institute Presidential Priorities Initiative , Blood Disorders Center , Leukemia Lymphoma Society , York Stem Cell Foundation , University Of Southern California , National Institutes Of Health , Broad Institute , Boston Children , Blood Disorders , Cell Genomics , Associate Member , Indigenous American , Latin America , National Institutes , New York Stem Cell Foundation , Lymphoma Society ,