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Decoding the interplay between genetic and non-genetic drivers of metastasis

Decoding the interplay between genetic and non-genetic drivers of metastasis
nature.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from nature.com Daily Mail and Mail on Sunday newspapers.

Al Bakir , Malagoli Tagliazucchi , Vander Velde , Sousae Melo , Us National Library Of Medicine , Transcriptome Core Group , Cancer Analysis Of Whole Genomes Consortium , Core Group , Cancer Analysis , Whole Genomes , Stem Cell , Cancer Genome Atlas , Cell Biol , Metastasis Rev , Cancer Res , Big Bang , Posthumous Evaluation , Advanced Cancer Environment , Acids Res ,

NIH Releases Proteogenomic Dataset for Cancer Research Breakthroughs

NIH Releases Proteogenomic Dataset for Cancer Research Breakthroughs
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Henry Rodriguez , National Cancer Institute , Division Of Cancer Treatment , Clinical Proteomic Tumor Analysis Consortium , Biden Harris Administration Cancer Moonshot , Cancer Data Service , Cancer Research Data Commons , National Institutes Of Health , National Institutes , Cancer Cell , Biden Harris Administration , Cancer Moonshot , Research Data Commons , Proteomic Data Commons , Genomic Data Commons , Cancer Treatment , National Cancer , Cancer Proteogenomics Connects Oncogenic Drivers , Cancer Analysis ,

Therapy-induced APOBEC3A drives evolution of persistent cancer cells

Acquired drug resistance to anticancer targeted therapies remains an unsolved clinical problem. Although many drivers of acquired drug resistance have been identified1–4, the underlying molecular mechanisms shaping tumour evolution during treatment are incompletely understood. Genomic profiling of patient tumours has implicated apolipoprotein B messenger RNA editing catalytic polypeptide-like (APOBEC) cytidine deaminases in tumour evolution; however, their role during therapy and the development of acquired drug resistance is undefined. Here we report that lung cancer targeted therapies commonly used in the clinic can induce cytidine deaminase APOBEC3A (A3A), leading to sustained mutagenesis in drug-tolerant cancer cells persisting during therapy. Therapy-induced A3A promotes the formation of double-strand DNA breaks, increasing genomic instability in drug-tolerant persisters. Deletion of A3A reduces APOBEC mutations and structural variations in persister cells and delays t ....

Cancer Analysis Of Whole Genomes Consortium , Transl Med , Cancer Analysis , Whole Genomes , Genome Biol , Acids Res ,

Study Reveals How Epstein-Barr Virus May Lead to Cancer

Study Reveals How Epstein-Barr Virus May Lead to Cancer
nih.gov - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from nih.gov Daily Mail and Mail on Sunday newspapers.

United States , La Jolla , University Of California San Diego , Julia Su Zhou Li , Lawrence Tabak , Don Cleveland , Cancer Analysis Of Whole Genomes Consortium , Sclerosis National Institute Of Neurological Disorders , Epstein Barr Virus Centers For Disease , Neck Cancer National Institute , Clinical Center , Donny Bliss , California San Diego , Ludwig Cancer Research , Pan Cancer Analysis , Whole Genomes , Cancer Analysis , Epstein Barr Virus , Disease Control , Neck Cancer , National Cancer Institute , National Institute , Neurological Disorders ,

Pan-Cancer Analysis Suggests Fibroblast Activation Protein (FAP) is an Attractive Target for Peptide-Targeted Radionuclide Therapy with FAP-2286

Pan-Cancer Analysis Suggests Fibroblast Activation Protein (FAP) is an Attractive Target for Peptide-Targeted Radionuclide Therapy with FAP-2286
sharewise.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sharewise.com Daily Mail and Mail on Sunday newspapers.

United States , Thomas Harding , Tanyat Kwan , Clovis Oncology Inc , Virtual International Conference On Molecular , Pb Pharmaceuticals , B Pharmaceuticals Gmb , Clovis Oncology , International Conference , Molecular Targets , Cancer Therapeutics , Pharmaceuticals Gmbh , Executive Vice President , Chief Scientific Officer , Cancer Analysis , Fibroblast Activation Protein Alpha , Guide Tumor Selection , Peptide Targeted Radionuclide Therapy , Targeted Radionuclide Therapy ,