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Dr Jhaveri on the Rationale for the ELAINE-3 Trial in ESR1-Mutant ER+/HER2– Breast Cancer

Komal Jhaveri, MD, FACP, discusses the rationale for investigating lasofoxifene alongside abemaciclib in ESR1-mutated estrogen receptor–positive, HER2-negative metastatic breast cancer. ....

James Cayne , Komal Jhaveri , Memorial Sloan Kettering Cancer Center , Early Drug Development Service , Endocrine Therapy Research Program , James Cayne Chair , Junior Faculty , Elaine 3 , Elaine 1 , Elaine 2 , Esr1 Mutant , Er Her2 Negative Breast Cancer ,

Dr Graff on the Relation Between ctDNA Positivity and Disease Recurrence in HR+/HER2– Breast Cancer

Stephanie L. Graff, MD, discusses findings from a pilot study exploring the association between disease recurrence and circulating tumor DNA positivity in patients with hormone receptor–positive, HER2-negative, node-positive, high-risk, early breast cancer who have received adjuvant treatment of abemaciclib and endocrine therapy.
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San Antonio , United States , Stephaniel Graff , Breast Cancer Translational Research Disease Group , Warren Alpert Medical School , Lifespan Cancer Institute , Brown University Legorreta Cancer Center , Brown University , Legorreta Cancer Center , Antonio Breast Cancer Symposium , Onclive Tv , Breast Cancer , Endocrine Therapy Interruption , Hr Positive Breast Cancer , Her2 Negative ,

Adjuvant Abemaciclib Plus Endocrine Therapy Sustains iDFS, DRFS Benefit in HR+, HER2– Early Breast Cancer

Adjuvant treatment with the combination of abemaciclib and endocrine therapy (ET) maintained a benefit in invasive disease-free survival and distant relapse–free survival compared with ET alone in patients with hormone receptor-positive, HER2-negative, node-positive, high-risk early breast cancer. ....

Eli Lilly , David Hyman , Kaplan Meier , P Ann Onc , Nadia Harbeck , Breast Center , Department Of Gynecology , Cancer Center Munich , Ludwig Maximilians University Hospital , Comprehensive Cancer Center Munich , Lancet Oncology , Monarche Trial , Hr Positive Breast Cancer , Hormone Receptor Positive Breast Cancer , Esmo Congress ,

Addition of Adjuvant Abemaciclib Reduces Recurrence at 5 Years in HR+, HER2– High-Risk Early Breast Cancer

Results of the monarchE study showed patients with hormone receptor–positive (HR+), HER2-negative (HER2–) high-risk, early breast cancer had greater benefit after 5 years when receiving adjuvant abemaciclib plus endocrine therapy vs endocrine therapy alone. ....

Klinikum Nadia Harbeck , Nadia Harbeck , Breast Center , University Hospital , Esmo Congress , Breast Cancer ,

HR+/HER2- Breast Cancer: Inhibiting the PI3K/AKT/mTOR Pathway

Dr Vidal expands on use of PI3K/AKT/mTOR pathway inhibitors following frontline progression, focusing on the PI3K inhibitor alpelisib for patients with PIK3CA mutations, as well as capivasertib, an AKT inhibitor in development. ....

Aditya Bardia , Gregory Vidal , Komal Jhaveri , Hr Her2 Breast Cancer , Cdk4 6 Inhibitors , Second Line Therapies , Endocrine Therapy , Endocrine Resistance , Akt Inhibitors , Capitello 291 , Maintain Trial , Ember 3 , Oral Serds , Viktoria 1 ,