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The Breast Cancer Index Impacts Physicians' Decision to Extend Endocrine Therapy for HR+ Early-Stage Disease

Incorporating the Breast Cancer Index test assay into practice affected clinicians’ decision to offer endocrine therapy in HR+ early-stage disease. ....

Tara Sanft , Medicine At Yale School Of , Journal Of The National Comprehensive Cancer Network , Breast Cancer Index , National Comprehensive Cancer Network , Yale School , Smilow Cancer Hospital , New Haven , Breast Cancer , Hormone Receptor Positive Breast Cancer , Endocrine Therapy , Yale School Of Medicine ,

Sacituzumab govitecan shows survival benefit in endocrine-resistant hormone-positive metastatic breast cancer

1. Median overall survival increased by 3.2 months in the sacituzumab govitecan group compared to chemotherapy. 2. One fatal treatment-related adverse event was reported in the sacituzumab group. Evidence Rating Level: 1 (Excellent) Study Rundown: In phase 3 of the TROPiCS-02 trial, sacituzumab govitecan demonstrated significant survival benefit versus chemotherapy among patients with hormone-receptor-positive (HR+) ....

United States , Sacituzumab Govitecan , Rating Level , Metastatic Triple Negative Breast , Between May , North America , Breast Cancer , Hormone Receptor Positive Breast Cancer , Metastatic Breast Cancer , Chronic Disease ,

Adjuvant Abemaciclib Plus Endocrine Therapy Sustains iDFS, DRFS Benefit in HR+, HER2– Early Breast Cancer

Adjuvant treatment with the combination of abemaciclib and endocrine therapy (ET) maintained a benefit in invasive disease-free survival and distant relapse–free survival compared with ET alone in patients with hormone receptor-positive, HER2-negative, node-positive, high-risk early breast cancer. ....

Eli Lilly , David Hyman , Kaplan Meier , P Ann Onc , Nadia Harbeck , Breast Center , Department Of Gynecology , Cancer Center Munich , Ludwig Maximilians University Hospital , Comprehensive Cancer Center Munich , Lancet Oncology , Monarche Trial , Hr Positive Breast Cancer , Hormone Receptor Positive Breast Cancer , Esmo Congress ,

ADCs, CDK4/6 Inhibitors, and SERDs Broaden HR+ and Triple-Negative Breast Cancer Treatment Paradigms

Novel data with trastuzumab deruxtecan, sacituzumab govitecan, and ribociclib have demonstrated an influx of overall survival advantages compared with standard-of-care regimens across breast cancer patient subsets, including HER2-positive, hormone receptor–positive, and triple-negative disease. ....

United States , Heather Mcarthur , Joyce Oshaughnessy , Breast Cancer Program , Ut Southwestern Medical Center , Department Of Internal Medicine , Clinical Breast Cancer Research , Baylor Charlesa Sammons Cancer Center , Division Of Hematology , Komen Distinguished Chair , Internal Medicine , Medical Center , Shanu Modi , Joyceo Shaughnessy , Texas Oncology Baylor Charles , Cancer Center , Trastuzumab Deruxtecan , Sacituzumab Govitecan , Overall Survival , Her2 Positive Breast Cancer , Hormone Receptor Positive Breast Cancer , Triple Negative Breast Cancer ,

Dr Tarantino on the Expansion of Treatment Options Post-CDK4/6 Inhibition in HR+ Breast Cancer

Paolo Tarantino, MD, discusses the expansion and selection of effective treatment options for patients with hormone receptor-positive breast cancer who progressed on a CDK 4/6 inhibitor. ....

Paolo Tarantino , Dana Farber Cancer Institute , European Institute Of Oncology , European Institute , Breast Cancer , Onclive Tv , Ost Cdk4 6 , Hormone Receptor Positive Breast Cancer ,