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Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people

Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people
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Bioscience nagahamaFluidigm snptypeJapan public health prospectiveEpidemiologic research program at aichi cancer centerTohoku medical megabank communityHospital based epidemiologic research programAichi cancer centerJapan multi institutional collaborative cohortJapan public health center based prospectiveTohoku medical megabank community based cohortNagahama prospective cohortComprehensive human bioscienceBiobank japanSupplementary materialsProject phaseEast asian

H Pylori, Pathogenic Variants Interact to Increase Risk of Gastric Cancer

H pylori infection may further increase the risk of gastric cancer associated with germline pathogenic variants in cancer-predisposing genes.

Epidemiologic research program at aichi cancer centerHealthday newsNew england journalHospital based epidemiologic research programAichi cancer

Helicobacter pylori, Homologous Recombination Genes, and Risk of Gastric Cancer

1. The following genes had statistically significant increased odds ratio of gastric cancer; BRCA2, ATM, BRCA1, MLH1, PALB2, APC, MSH6, MSH2, CDH1. 2. Patients with H. pylori infection and a pathogenic variant had a higher cumulative risk of gastric cancer than noncarriers infected with H. pylori (45.5% vs. 14.4%) at 85 years of age. Evidence

Epidemiologic research program at aichi cancer centerRating levelFamily historyGastric cancerBiobank japanEpidemiologic research programAichi cancer centerH pyloriHomologous recombination genes

A Double Whammy for Gastric Cancer Risk

<em>H. pylori</em> infection and certain pathogenic variants linked with large excess risk

United statesMike bassettYukihide momozawaEpidemiologic research program at aichi cancer centerIntegrative medical sciencesUniversity of zurichNew england journalDouble whammyGastric cancer riskBiobank japanHospital based epidemiologic research programAichi cancer centerEngland journalEnglj med

Genetic variants increase risk for H pylori -related stomach cancer

Individuals with certain germline pathogenic variants had a substantially higher risk for developing gastric cancer after Helicobacter pylori infection, results of a Japan-based case-control study showed.The findings, published in The New England Journal of Medicine, suggest risk for gastric cancer is more heavily related to hereditary factors than previously thought, the investigators noted.

Yoshiaki usuiYukihide momozawaLaboratory for genotyping developmentEpidemiologic research program at aichi cancer centerIntegrative medical sciencesThenew england journalEast asianGenotyping developmentBiobank japanHospital based epidemiologic research programAichi cancer centerMolecular cancer research