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H Pylori, Pathogenic Variants Interact to Increase Risk of Gastric Cancer

H pylori infection may further increase the risk of gastric cancer associated with germline pathogenic variants in cancer-predisposing genes.

A Double Whammy for Gastric Cancer Risk

Genetic variants increase risk for H pylori -related stomach cancer

Individuals with certain germline pathogenic variants had a substantially higher risk for developing gastric cancer after Helicobacter pylori infection, results of a Japan-based case-control study showed.The findings, published in The New England Journal of Medicine, suggest risk for gastric cancer is more heavily related to hereditary factors than previously thought, the investigators noted.

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