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CNN The Lead With Jake Tapper September 17, 2024

Breaking news, Authority Say Donald Trump has the highest level of protection, right . Now including this security over at maralago after the apparent attempt to assassinate the nba on the Golf Course. Standby for all the new information from authorities that just came in minutes ago on the suspect and on the Investigation Welcome to our viewers here in the United States and around the world. Im wolf blitzer. Youre in the Situation Room Breaking News or lets get right to the Breaking News on the second apparent attempt to assassinate Donald Trump. The fbi now describing its investigation as quote, extremely serious during a Briefing And Florida Just A Little while ago, cnns Paula Reid is thomas scene for us in West Palm Beach, florida right now, paula, what stood out to you from this update hearing the Secret Service defending its Protection Plan for former President Trump anna, feeling that the suspect did not have a clear line of sight to the former president. Investigation down here

Bimekizumab safe and effective for treatment of moderate-to-severe hidradenitis suppurative

1. Significantly more patients in the bimekizumab group than placebo reported improved clinical response at week 16. 2. Treatment-related adverse events were infrequent with one fatality across both treatment groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Hidradenitis suppurativa (HiS) is a chronic inflammatory disease with limited therapeutic options. Bimekizumab, a monoclonal IgG1 antibody that

Genome sequencing may offer diagnostic utility beyond exome sequencing at acceptable cost

1. In this cohort study of families with suspected Mendelian disorders for whom preliminary genetic testing had not revealed a diagnosis, nearly one-third of families obtained a plausible molecular diagnosis after genome sequencing. 2. While enhancing prior exome sequencing likely would have revealed the causal variants in most cases, over one-quarter of the new diagnoses

Zodasiran associated with reduced triglyceride levels among adults with mixed hyperlipidemia

1. In this randomized controlled trial, adults with mixed hyperlipidemia who received zodasiran had dose-dependent decreases in triglyceride levels compared to those who received placebo. 2. Patients who received the highest dose of zodasiran had transiently increased glycated hemoglobin levels, returning to baseline with treatment. Evidence Rating Level: 1 (Excellent) Study Rundown: Mixed hyperlipidemia is

Aficamten improves oxygen uptake in patients with obstructive hypertrophic cardiomyopathy

1. In this randomized controlled trial, aficamten significantly improved peak oxygen uptake in patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM) compared with placebo. 2. The results for all 10 secondary endpoints were significantly improved with aficamten. Evidence Rating Level: 1 (Excellent) Study Rundown: HCM is one of the most common genetic heart diseases and is

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