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Weizmann Institute Uncovers Secret of Hunger Switch in the Brain | The Jewish Press - JewishPress.com | Jewish Press News Desk | 4 Iyyar 5781 – April 16, 2021

Photo Credit: Image by Gerd Altmann from Pixabay
Being constantly hungry, no matter how much you eat â that’s the daily struggle of people with genetic defects in the brain’s appetite controls, and it often ends in severe obesity. In a study published in Science on April 15, researchers at the Weizmann Institute of Science, together with colleagues from the Queen Mary University of London and the Hebrew University of Jerusalem, have revealed the mechanism of action of the master switch for hunger in the brain: the melanocortin receptor 4, or MC4 receptor for short. They have also clarified how this switch is activated by setmelanotide (Imcivree), a drug recently approved for the treatment of severe obesity caused by certain genetic changes. These findings shed new light on the way hunger is regulated and may help develop improved anti-obesity medications. ....

Israel General , Moran Shalev Benami , Oksana Degtjarik , Vadivel Prabahar , Gerd Altmann , Yoav Peleg , Fabrizio Fierro , Nicolasj Roth , Vidicha Chunilal , Peterj Mccormick , Lif Chan , Danny Ben Zvi , Amandeep Kaur Gill , Joaquin Botta , Weizmann Institute Of Science , Tauro Career Development , Leadership Program , Wolf Lebovic Lab , Magnetic Resonance Research , Weizmann Life Sciences Core Facilities Department , Queen Mary University Of London , Hebrew University Of Jerusalem , Ilse Katz Institute For Material Sciences , Structural Biology Department , Biomedical Research , Photo Credit ,

The Hunger Games: Uncovering the Secret of the Hunger Switch in the Brain - Chemistry | Weizmann Wonder Wander

Being constantly hungry, no matter how much you eat, is a daily struggle for people with genetic defects in the brain s appetite controls, and it often ends in severe obesity. In a study published in
Science on April 15, researchers at the Weizmann Institute of Science, together with colleagues from the Queen Mary University of London and the Hebrew University of Jerusalem, have revealed the mechanism of action of the master switch for hunger in the brain: the melanocortin receptor 4, or MC4 receptor for short. They have also clarified how this switch is activated by setmelanotide (Imcivree), a drug recently approved for the treatment of severe obesity caused by certain genetic changes. These findings shed new light on the way hunger is regulated and may help develop improved anti-obesity medications. ....

Israel General , Moran Shalev Benami , Oksana Degtjarik , Vadivel Prabahar , Fabrizio Fierro , Yoav Peleg , Nicolasj Roth , Vidicha Chunilal , Peterj Mccormick , Lif Chan , Danny Ben Zvi , Amandeep Kaur Gill , Joaquin Botta , Weizmann Life Sciences Core Facilities Department , Queen Mary University Of London , Hebrew University Of Jerusalem , Weizmann Institute Of Science , Structural Biology Department , Weizmann Institute , Queen Mary University , Hebrew University , Hadar Israeli , Life Sciences Core Facilities , இஸ்ரேல் ஜநரல் , டேனி பென் ஸ்வை , வெய்ஸ்மேன் வாழ்க்கை அறிவியல் கோர் வசதிகள் துறை ,

The Hunger Games: Uncovering the secret of the hunger switch in the brain

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Being constantly hungry, no matter how much you eat - that s the daily struggle of people with genetic defects in the brain s appetite controls, and it often ends in severe obesity. In a study published in
Science on April 15, researchers at the Weizmann Institute of Science, together with colleagues from the Queen Mary University of London and the Hebrew University of Jerusalem, have revealed the mechanism of action of the master switch for hunger in the brain: the melanocortin receptor 4, or MC4 receptor for short. They have also clarified how this switch is activated by setmelanotide (Imcivree), a drug recently approved for the treatment of severe obesity caused by certain genetic changes. These findings shed new light on the way hunger is regulated and may help develop improved anti-obesity medications. ....

Israel General , Moran Shalev Benami , Oksana Degtjarik , Vadivel Prabahar , Fabrizio Fierro , Yoav Peleg , Nicolasj Roth , Vidicha Chunilal , Peterj Mccormick , Lif Chan , Danny Ben Zvi , Amandeep Kaur Gill , Joaquin Botta , Weizmann Institute Of Science , Tauro Career Development , Leadership Program , Wolf Lebovic Lab , Magnetic Resonance Research , Weizmann Life Sciences Core Facilities Department , Queen Mary University Of London , Hebrew University Of Jerusalem , Ilse Katz Institute For Material Sciences , Structural Biology Department , Biomedical Research , Weizmann Institute , Queen Mary University ,

Stress Response Protein Links Inflammatory Disease to Colon Cancer

Weizmann Institute of Science
The findings might help identify those at extra risk of this cancer and develop means of prevention
Inflammation promotes some of the deadliest cancers. In the colon, inflammatory bowel disease is well known to be associated with higher-than-average rates of malignancy. Nevertheless, the developing tumor is commonly diagnosed only when it has already advanced or even metastasized, possibly because the early symptoms of malignancy are often mistakenly ascribed to a flare-up of intestinal inflammation. Weizmann Institute of Science researchers have now revealed a molecular missing link between chronic gut inflammation and cancer. This revelation may help develop ways of preventing colon cancers in people with inflammatory diseases of the intestines. ....

New York , United States , Memorial Sloan Kettering Cancer Center , City Of , United Kingdom , Shimrit Mayer , Liorh Katz , Gil Friedman , Reinat Nevo , Ido Laish , Hagar Lavon , Ruth Scherz Shouval , Aliza Yemini , David Kelsen , Johna Porco , Ofra Golani , Rina Wassermann Dozorets , Rona Yaeger , Laurene Brown , Yaniv Stein , Drors Shouval , Erik Sahai , Esther Wershof , Wenhan Zhang , Meirav Pevsner Fischer , Oshrat Levi Galibov ,