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21 Apr 2021 Share: Ever stood at your refridgerator staring into it and wishing you could switch off the hunger pangs that took you there in the first place? Now, with the help of one family s genetic disposition to suffer uncontrollable and persistent hunger, researchers have uncovered the mechanism of action of the master switch for hunger in the brain shedding new light on the way hunger is regulated. Results have uncovered a 3D structure that reveals how a unique molecular switch in our brain causes us to feel full - and may help develop improved anti-obesity drugs. Being constantly hungry, no matter how much you eat - that s the daily struggle of people with genetic defects in the brain s appetite controls, and it often ends in severe obesity. ....
Photo Credit: Image by Gerd Altmann from Pixabay Being constantly hungry, no matter how much you eat â that’s the daily struggle of people with genetic defects in the brain’s appetite controls, and it often ends in severe obesity. In a study published in Science on April 15, researchers at the Weizmann Institute of Science, together with colleagues from the Queen Mary University of London and the Hebrew University of Jerusalem, have revealed the mechanism of action of the master switch for hunger in the brain: the melanocortin receptor 4, or MC4 receptor for short. They have also clarified how this switch is activated by setmelanotide (Imcivree), a drug recently approved for the treatment of severe obesity caused by certain genetic changes. These findings shed new light on the way hunger is regulated and may help develop improved anti-obesity medications. ....
Being constantly hungry, no matter how much you eat, is a daily struggle for people with genetic defects in the brain s appetite controls, and it often ends in severe obesity. In a study published in Science on April 15, researchers at the Weizmann Institute of Science, together with colleagues from the Queen Mary University of London and the Hebrew University of Jerusalem, have revealed the mechanism of action of the master switch for hunger in the brain: the melanocortin receptor 4, or MC4 receptor for short. They have also clarified how this switch is activated by setmelanotide (Imcivree), a drug recently approved for the treatment of severe obesity caused by certain genetic changes. These findings shed new light on the way hunger is regulated and may help develop improved anti-obesity medications. ....
E-Mail Being constantly hungry, no matter how much you eat - that s the daily struggle of people with genetic defects in the brain s appetite controls, and it often ends in severe obesity. In a study published in Science on April 15, researchers at the Weizmann Institute of Science, together with colleagues from the Queen Mary University of London and the Hebrew University of Jerusalem, have revealed the mechanism of action of the master switch for hunger in the brain: the melanocortin receptor 4, or MC4 receptor for short. They have also clarified how this switch is activated by setmelanotide (Imcivree), a drug recently approved for the treatment of severe obesity caused by certain genetic changes. These findings shed new light on the way hunger is regulated and may help develop improved anti-obesity medications. ....
Science, has revealed how the master switch for hunger in the brain, the melanocortin receptor 4 (MC4), works. The research team, including scientists from the Weizmann Institute of Science, Queen Mary University of London and the Hebrew University of Jerusalem, also clarified how this switch is activated by setmelanotide (Imcivree), a drug recently approved for the treatment of severe obesity caused by certain genetic changes. The findings shed new light on the way hunger is regulated and could help to develop improved anti-obesity medications. Unexpected finding The study uncovered the 3D structure of the MC4 receptor, through the use of recent advances in cryogenic electron microscopy. The 3D structure revealed that setmelanotide activates the MC4 receptor by entering its binding pocket –directly hitting the molecular switch that triggers us to feel full- even more potently than the natural satiety hormone. It also turned out that the drug has a surprising hel ....