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Need to migrate legacy business logic to cloud-native? Here s how

SHARE Translating legacy code to a modern language is only part of the answer. Transitioning to cloud-native architectures is the greater challenge. For decades, information technology executives were faced with two unpalatable options for legacy application modernization: “Rip and replace” or “Leave and layer.” When a legacy application still provides value, ripping and replacing is a high-risk option. The replacement may not adequately meet the needs of the organization, and the transition from old to new may be overly disruptive to the enterprise. However, the leave-and-layer approach isn’t much better. True, adding application programming interfaces or connectors to a legacy application can extend its lifetime, as can leveraging robotic process automation to script its user interface.

Weekly roundup of world briefs

Weekly roundup of world briefs
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The Hunger Games: Uncovering the secret of the hunger switch in the brain

21 Apr 2021 Share: Ever stood at your refridgerator staring into it and wishing you could switch off the hunger pangs that took you there in the first place? Now, with the help of one family s genetic disposition to suffer uncontrollable and persistent hunger, researchers have uncovered the mechanism of action of the master switch for hunger in the brain shedding new light on the way hunger is regulated. Results have uncovered a 3D structure that reveals how a unique molecular switch in our brain causes us to feel full - and may help develop improved anti-obesity drugs. Being constantly hungry, no matter how much you eat - that s the daily struggle of people with genetic defects in the brain s appetite controls, and it often ends in severe obesity.

Israeli scientists find brain s hunger switch | US & World News

When Hebrew University of Jerusalem medical student Hadar Israeli studied a family with multiple members suffering from severe obesity and plagued with constant hunger, she found that they all shared a common mutation affecting a specific receptor in the brain: Melanocortin Receptor 4, or MC4. Though scientists have long known that the MC4 receptor was in some way connected to hunger and appetite, Israeli helped uncover just how instrumental it was in regulating our sensations of hunger and fullness. To further investigate this matter, Israeli turned to Moran Shalev-Benami of the Weizmann Institute’s chemical and structural biology department. Could new advances in electron microscopy help explain how this mutation produces such a devastating effect of constant hunger?

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