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Weizmann Institute Uncovers Secret of Hunger Switch in the Brain | The Jewish Press - JewishPress.com | Jewish Press News Desk | 4 Iyyar 5781 – April 16, 2021

Photo Credit: Image by Gerd Altmann from Pixabay
Being constantly hungry, no matter how much you eat â that’s the daily struggle of people with genetic defects in the brain’s appetite controls, and it often ends in severe obesity. In a study published in Science on April 15, researchers at the Weizmann Institute of Science, together with colleagues from the Queen Mary University of London and the Hebrew University of Jerusalem, have revealed the mechanism of action of the master switch for hunger in the brain: the melanocortin receptor 4, or MC4 receptor for short. They have also clarified how this switch is activated by setmelanotide (Imcivree), a drug recently approved for the treatment of severe obesity caused by certain genetic changes. These findings shed new light on the way hunger is regulated and may help develop improved anti-obesity medications. ....

Israel General , Moran Shalev Benami , Oksana Degtjarik , Vadivel Prabahar , Gerd Altmann , Yoav Peleg , Fabrizio Fierro , Nicolasj Roth , Vidicha Chunilal , Peterj Mccormick , Lif Chan , Danny Ben Zvi , Amandeep Kaur Gill , Joaquin Botta , Weizmann Institute Of Science , Tauro Career Development , Leadership Program , Wolf Lebovic Lab , Magnetic Resonance Research , Weizmann Life Sciences Core Facilities Department , Queen Mary University Of London , Hebrew University Of Jerusalem , Ilse Katz Institute For Material Sciences , Structural Biology Department , Biomedical Research , Photo Credit ,

The Hunger Games: Uncovering the secret of the hunger switch in the brain

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Being constantly hungry, no matter how much you eat - that s the daily struggle of people with genetic defects in the brain s appetite controls, and it often ends in severe obesity. In a study published in
Science on April 15, researchers at the Weizmann Institute of Science, together with colleagues from the Queen Mary University of London and the Hebrew University of Jerusalem, have revealed the mechanism of action of the master switch for hunger in the brain: the melanocortin receptor 4, or MC4 receptor for short. They have also clarified how this switch is activated by setmelanotide (Imcivree), a drug recently approved for the treatment of severe obesity caused by certain genetic changes. These findings shed new light on the way hunger is regulated and may help develop improved anti-obesity medications. ....

Israel General , Moran Shalev Benami , Oksana Degtjarik , Vadivel Prabahar , Fabrizio Fierro , Yoav Peleg , Nicolasj Roth , Vidicha Chunilal , Peterj Mccormick , Lif Chan , Danny Ben Zvi , Amandeep Kaur Gill , Joaquin Botta , Weizmann Institute Of Science , Tauro Career Development , Leadership Program , Wolf Lebovic Lab , Magnetic Resonance Research , Weizmann Life Sciences Core Facilities Department , Queen Mary University Of London , Hebrew University Of Jerusalem , Ilse Katz Institute For Material Sciences , Structural Biology Department , Biomedical Research , Weizmann Institute , Queen Mary University ,