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New bioprinting process uses ultrashort peptides to print hydrogel scaffolds A new automated process prints a peptide-based hydrogel scaffold containing uniformly distributed cells. The scaffolds hold their shapes well and successfully facilitate cell growth that lasts for weeks. Bioprinting 3D printing that incorporates living cells has the potential to revolutionize tissue engineering and regenerative medicine. Scientists have experimented with natural and synthetic bioinks to print out scaffolds that hold cells in place as they grow and form a tissue with a specific shape. But there are challenges with cell survival. Natural bioinks, such as gelatin and collagen, need to be treated with chemicals or ultraviolet light to hold their shape, which affects the cell viability. The synthetic polymer hydrogels tested to date also require the use of harsh chemicals and conditions that threaten cell survival. ....
AI-based technique determines cancer cells by their acidity Healthy and cancer cells can look similar under a microscope. One way of differentiating them is by examining the level of acidity, or pH level, inside the cells. Tapping on this distinguishing characteristic, a research team from the National University of Singapore (NUS) has developed a technique that uses artificial intelligence (AI) to determine whether a single cell is healthy or cancerous by analyzing its pH. Each cancer test can be completed in under 35 minutes, and single cells can be classified with an accuracy rate of more than 95 per cent. The research, led by Professor Lim Chwee Teck, Director of the Institute for Health Innovation & Technology (iHealthtech) at NUS, was first published in the journal ....
Study shows how functional biomaterials rely on interfacial protein layer to transmit signals to living cells An interdisciplinary research team at Lehigh University has unraveled how functional biomaterials rely upon an interfacial protein layer to transmit signals to living cells concerning their adhesion, proliferation and overall development. According to an article published today in Scientific Reports, the nanoscale features and properties of an underlying substrate do not impact the biological response of cells directly. However, these properties indirectly influence cell behavior through their control over adsorbed proteins. In the article, Nanostructure of bioactive glass affects bone cell attachment via protein restructuring upon adsorption, the Lehigh team demonstrates that living cells respond to interfacial layer characteristics that arise as a consequence of micro- and nano-scale structures engineered into a substrate material. ....
Researchers use EPR spectroscopy to learn more about Parkinson protein The protein α-synuclein is one of the most abundant proteins in the human brain. It is often referred to as the Parkinson protein , as deposition of this protein in brain cells is a hallmark of Parkinson s disease. Despite the high interest of biomedical research in the protein, many questions concerning the function and physiology of α-synuclein in living cells still remain to be answered. For example, it was previously unclear whether and to what extent the protein binds to and interacts with internal cell components such as membranes. As such processes could play a role in the development of the disease, the team led by Konstanz-based physical chemist Professor Malte Drescher used the further development of an established measurement method called electron paramagnetic resonance spectroscopy (EPR spectroscopy) to learn more about the binding properties of the Parkinson protein . ....
Whole genome sequencing may guide blood cancer treatment For certain blood cancers, such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), deciding whether patients need an aggressive treatment typically hinges on a set of lab tests to identify genetic changes. Some of these tests rely on technology that was invented more than 60 years ago and has been used clinically for the past three decades. Now, a new study from Washington University School of Medicine in St. Louis shows that whole genome sequencing is at least as accurate and often better than conventional genetic tests that help determine the treatment for a patient s blood cancer. Genome sequencing technology continuously is decreasing in cost and recently reached a level similar to that of conventional testing. In addition, results can be returned to patients in just a few days, making whole genome sequencing a potentially viable approach for determining the best treatment regimen for a parti ....