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E-Mail IMAGE: A schematic visualization of the ferritin nanoparticle with shortened coronavirus spike proteins, which is the basis of a SARS-CoV-2 vaccine candidate from Stanford. view more Credit: Duo Xu Before the pandemic, the lab of Stanford University biochemist Peter S. Kim focused on developing vaccines for HIV, Ebola and pandemic influenza. But, within days of closing their campus lab space as part of COVID-19 precautions, they turned their attention to a vaccine for SARS-CoV-2, the virus that causes COVID-19. Although the coronavirus was outside the lab s specific area of expertise, they and their collaborators have managed to construct and test a promising vaccine candidate. ....
by Karishma Abhishek on December 22, 2020 at 10:51 PM COVID-19 causing coronaviruses have protein spikes on their surfaces that help the virus bind with the host receptors cells - first step of infection. Scientists have decoded the first detailed images of those spikes in their natural state, while still attached to the virus using cryogenic electron microscopy (cryo-EM) and computation techniques as per a study published in the journal Quarterly Reviews Biophysics Discovery. This serves as the critical step in designing therapeutic drugs and vaccines against the virus. The advantage of doing it this way is that when you purify a spike protein and study it in isolation, you lose important biological context: How does it look in an intact virus particle? It could possibly have a different structure there, says Wah Chiu, a professor at DOE s SLAC National Accelerator Laboratory and Stanford University and senior author of the stu ....
New research: Coronavirus spike protein imaged in its natural state Scientists have made detailed images of the coronavirus spikes in their natural state while they are still attached to the virus, and without using chemical fixatives that might distort their shape. Updated: December 21, 2020 2:20:56 pm Detailed structure of a spike from a coronavirus that is a milder relative of SARS-CoV-2 (K. Zhang et al., Quarterly Reviews of Biophysics Discovery) Coronaviruses including SARS-CoV-2, which causes Covid-19, get their name from the “corona” or crown shape created by the protein “spikes” on their surface. These spike proteins bind with human proteins to initiate the process of infection. These spikes have been extensively studied during the pandemic. Now, scientists have made detailed images of those spikes in their natural state while they are still attached to the virus, and without using chemical fixatives that might distor ....
E-Mail IMAGE: This rotating image shows the detailed structure of a spike from a coronavirus that causes cold symptoms - a milder relative of the virus that causes COVID-19. Spikes bind to. view more Credit: K. Zhang et al., Quarterly Reviews of Biophysics Discovery, 2020 Coronaviruses like the one that causes COVID-19 are studded with protein spikes that bind with receptors on the cells of their victims - the first step in infection. Now scientists have made the first detailed images of those spikes in their natural state, while still attached to the virus and without using chemical fixatives that might distort their shape. ....