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Spike Protein of COVID-19 Virus Reveals It's Mechanism


by Karishma Abhishek on 
December 22, 2020 at 10:51 PM
COVID-19 causing coronaviruses have protein spikes on their surfaces that help the virus bind with the host receptors cells - first step of infection. Scientists have decoded the first detailed images of those spikes in their natural state, while still attached to the virus using cryogenic electron microscopy (cryo-EM) and computation techniques as per a study published in the journal
Quarterly Reviews Biophysics Discovery.
This serves as the critical step in designing therapeutic drugs and vaccines against the virus.
The advantage of doing it this way is that when you purify a spike protein and study it in isolation, you lose important biological context: How does it look in an intact virus particle? It could possibly have a different structure there, says Wah Chiu, a professor at DOE s SLAC National Accelerator Laboratory and Stanford University and senior author of the stu ....

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Scientists get the most realistic view yet of a coronavirus spike's protein structure


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IMAGE: This rotating image shows the detailed structure of a spike from a coronavirus that causes cold symptoms - a milder relative of the virus that causes COVID-19. Spikes bind to.
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Credit: K. Zhang et al., Quarterly Reviews of Biophysics Discovery, 2020
Coronaviruses like the one that causes COVID-19 are studded with protein spikes that bind with receptors on the cells of their victims ­- the first step in infection. Now scientists have made the first detailed images of those spikes in their natural state, while still attached to the virus and without using chemical fixatives that might distort their shape. ....

Stanford University , United States , San Francisco , Kaiming Zhang , Jing Jin , Vitalant Research Institute , Office Of Science , National Institutes Of Health , National Virtual Biotechnology Laboratory , National Accelerator Laboratory , Wah Chiu , Accelerator Laboratory , Quarterly Reviews Biophysics , National Institutes , Quarterly Reviews Biophysics Discovery , ஸ்டான்போர்ட் பல்கலைக்கழகம் , ஒன்றுபட்டது மாநிலங்களில் , சான் பிரான்சிஸ்கோ , ஜிங் ஜின் , வைட்டலண்ட் ஆராய்ச்சி நிறுவனம் , அலுவலகம் ஆஃப் அறிவியல் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , தேசிய மெய்நிகர் உயிரி தொழில்நுட்பவியல் ஆய்வகம் , தேசிய முடுக்குப்பொறி ஆய்வகம் , வா சியு , முடுக்குப்பொறி ஆய்வகம் ,