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To combat gum disease, help oral bacteria evolve

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Tsukuba, Japan Liver disease, from metabolic and bacterial causes, is a growing concern. What connects these dots? The gut, or more specifically, bacteria in the gut. Bacteria that cause inflammation in the mouth are transported through the digestive tract to the gut and liver, where they can cause liver inflammation. Lipopolysaccharides, important structural molecules in some bacteria, act as endotoxins, producing systemic effects that can manifest as non-alcoholic fatty liver disease (NAFLD). Now, a multidisciplinary team from the University of Tsukuba show that exercise could be used to improve the oral environment in people with NAFLD, potentially leading to a new treatment for the disease. ....

Junichi Shoda , Public Health , International Journal Of Environmental Research , University Of Tsukuba , Professor Junichi , Oral Microbiota , Alcoholic Fatty Liver Disease , International Journal , Environmental Research , Medicine Health , Dentistry Periodontal Disease , Diet Body Weight , Metabolism Metabolic Diseases , பொது ஆரோக்கியம் , சர்வதேச இதழ் ஆஃப் சுற்றுச்சூழல் ஆராய்ச்சி , பல்கலைக்கழகம் ஆஃப் ட்சூகுபா , ஆல்கஹால் கொழுப்பு கல்லீரல் நோய் , சர்வதேச இதழ் , சுற்றுச்சூழல் ஆராய்ச்சி , உயிர் வேதியியல் , மருந்து ஆரோக்கியம் , பல் மருத்துவம் பெரியடாஂடல் நோய் , உணவு உடல் எடை , வளர்சிதை மாற்றம் வளர்சிதை மாற்ற நோய்கள் ,

NIH training grant enhances opportunities for biomedical graduate students at AU

Credit: Kim Ratliff, Augusta University
Augusta University has received a $1.5 million grant from the National Institutes of Health to help support the graduate education of future scientists whose focus is cardiometabolic diseases like hypertension and diabetes which disproportionally affect minorities.
The training grant (1HL155011-01A1) will support four graduate students in its first year, and scale up to six students per year by year four of the five-year grant. It will offer aspiring PhDs and MD/PhDs the opportunity to learn from 43 federally funded scientists focusing on different aspects of cardometabolic disease related to minority health. Student recruitment has just started. ....

United States , David Stepp , Jennifer Sullivan , School Ph , Cardiometabolic Training Program , Vascular Biology Center , College Of Georgia , Georgia Prevention Institute , National Institutes Of Health , School Core Course In Integrated Pathophysiology , Department Of Physiology , Augusta University , Biomedical Sciences Programs , National Institutes , Graduate School , Medical College , Leon Henri Charbonnier Endowed Chair , Cardiometabolic Training , Cellular Biology , Cancer Biology , Genomic Medicine , Molecular Medicine , Coral Biology , Maxillofacial Pathology , Experimental Therapeutics , Core Course ,

New research on good cholesterol possibly finds better marker for cardiovascular disease

Credit: Ulf Sirborn
Good cholesterol, which is transported in HDLs (high-density lipoproteins), plays a key part in the prevention of atherosclerosis and thus the risk of cardiovascular disease. However, according to a new paper co-authored by researchers at Karolinska Institutet in Sweden and published in the journal
Circulation, the anti-inflammatory properties of HDLs could be an even better biomarker for future cardiovascular events.
Atherosclerosis is considered a chronic local inflammation that leads to plaques in the blood vessels and that, if left untreated, can cause cardiovascular disease, the most common cause of death in the world.
The inflammation, while unnoticeable, can cause considerable damage to the blood vessels, so it is important to identify at-risk individuals as early as possible to curb progression of the disease. ....

Karolinska Institutet , Congzhuo Jia , Robin Pf Dullaart , Stephanjl Bakker , Uwe Tietge , Josephine Lc Anderson , Uwe Jf Tietge , Lung Foundation , Netherlands Organization For Scientific Research , University Of Groningen , Department Of Laboratory Medicine , Vascular End , Professor Uwe Tietge , Laboratory Medicine , Netherlands Organization , Scientific Research , Swedish Heart , Professor Tietge , Medicine Health , Internal Medicine , Metabolism Metabolic Diseases , நுரையீரல் அடித்தளம் , நெதர்லாந்து ஆர்கநைஸேஶந் க்கு அறிவியல் ஆராய்ச்சி , பல்கலைக்கழகம் ஆஃப் க்ராநிகந் , துறை ஆஃப் ஆய்வகம் மருந்து , ஆய்வகம் மருந்து ,

Is a calorie a calorie? Not always, when it comes to almonds

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IMAGE: Researchers at the University of Toronto have found that a calorie labelled is not the same as a calorie digested and absorbed, when the food source is almonds.
The findings.
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Credit: University of Toronto
Researchers at the University of Toronto have found that a calorie labelled is not the same as a calorie digested and absorbed, when the food source is almonds.
The findings should help alleviate concerns that almonds contribute to weight gain, which persist despite the widely recognized benefits of nuts as a plant-based source of protein, vitamins and minerals.
Nuts have generally been thought of as healthy the last two decades, but the messaging around nuts has often come with a disclaimer that they are high in fat and energy, said John Sievenpiper, principal investigator on the study and an associate professor in the departments of nutritional sciences and medicine at the Temerty Faculty of Medicine. ....

John Sievenpiper , Stephanie Nishi , Unity Health Toronto , University Of Toronto , Us National Cholesterol Education Program , University Of Rovirai Virgili , Temerty Faculty , Unity Health , Mayo Clinic Proceedings , Cholesterol Education Program , Nutrition Nutrients , Medicine Health , Diet Body Weight , Metabolism Metabolic Diseases , ஒற்றுமை ஆரோக்கியம் டொராண்டோ , பல்கலைக்கழகம் ஆஃப் டொராண்டோ , எங்களுக்கு தேசிய கொழுப்பு கல்வி ப்ரோக்ர்யாம் , ஒற்றுமை ஆரோக்கியம் , கொழுப்பு கல்வி ப்ரோக்ர்யாம் , ஊட்டச்சத்து ஊட்டச்சத்துக்கள் , மருந்து ஆரோக்கியம் , உணவு உடல் எடை , வளர்சிதை மாற்றம் வளர்சிதை மாற்ற நோய்கள் ,

Pain receptors linked to the generation of energy-burning brown fat cells

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BOSTON - (April 12, 2021) - A new source of energy expending brown fat cells has been uncovered by researchers at the Joslin Diabetes Center, which they say points towards potential new therapeutic options for obesity. According to the new report, published today by
Nature Metabolism, the key lies in the expression of a receptor called Trpv1 (temperature-sensitive ion channel transient receptor potential cation subfamily V member 1) a protein known to sense noxious stimuli, including pain and temperature.
Specifically, the authors point to smooth muscle cells expressing the Trpv1 receptor and identify them as a novel source of energy-burning brown fat cells (adipocytes). This should translate into increased overall energy expenditure - and ultimately, researchers hope, reduced weight. ....

United States , United Kingdom , Yu Hua Tseng , Anushka Gupta , Matthewd Lynes , University Of California , National Institute Of Diabetes , Joslin Diabetes Center , Tian Lian Huang Joslin Diabetes Center , American Diabetes Association , Us National Institutes Of Health , Li Lun Ho Massachusetts Institute Of Technology , Nature Metabolism , Mary Piper , Public Health , Massachusetts Institute , Tian Lian Huang , Aaron Streets , National Institute , Kidney Diseases , American Diabetes , Cell Biology , Molecular Biology , Eating Disorders Obesity , Metabolism Metabolic Diseases , ஒன்றுபட்டது மாநிலங்களில் ,