Despite knowing about decompression sickness - or the bends - for more than a century, researchers are still mystified about how this condition occurs. A new study published by the open access journal Frontiers is the first to explore the genetic changes that occur in humans with the bends. It reveals that genes involved in white blood cell activation and inflammation are upregulated in divers with this condition. The results may pave the way for tests that allow doctors to diagnose decompression sickness more easily.
New findings from the University of Minnesota Medical School are helping uncover why some people are more likely to be overweight and develop Type 2 diabetes and it starts in the womb.
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Chestnut Hill, Mass. (6/10/2021) - A British man who rejected the standard of care to treat his brain cancer has lived with the typically fatal glioblastoma tumor growing very slowly after adopting a ketogenic diet, providing a case study that researchers say reflects the benefits of using the body s own metabolism to fight this particularly aggressive cancer instead of chemo and radiation therapy.
Published recently in the journal
Frontiers in Nutrition, the report is the first evaluation of the use of ketogenic metabolic therapy (KMT) without chemo or radiation interventions, on a patient diagnosed with IDH1-mutant glioblastoma (GBM). Ketogenic therapy is a non-toxic nutritional approach, viewed as complementary or alternative, that uses a low-carbohydrate, high-fat diet to manage a range of cancers, including glioblastoma.
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IMAGE: In Alg mutant embryos, rod cells are initially born but not maintained and undergo programmed cell death indicated in magenta (TUNEL staining). view more
Credit: Clara Becker.
Human cells are kept healthy by the activity of millions of proteins. These proteins are modified in different ways, such as by adding sugar molecules to them, which can be crucial for them to function properly. Given this importance, defects in the sugar-adding process are often lethal at the very early stages of development. In rare cases, however, patients can develop sugar-adding deficiencies that result in a range of metabolic diseases, known collectively as congenital disorders of glycosylation (CDG). These disorders are caused by defects in the enzymes involved in the sugar-adding process. For example, ALG2-CDG (or CDG-Ii) is a disorder caused by mutations in the ALG2 enzyme, which combines sugar molecules together. ALG2-CDG patients appear unaffected at birth, but later d
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Obesity is generally linked to poor eating habits and the availability of tasty, high-calorie foods. However, a new study led by researchers from the Magnetic Resonance Imaging Research Unit in the Department of Radiology at Hospital del Mar and the Barcelona Institute for Global Health (ISGlobal), a centre supported by the la Caixa Foundation, has found that more elements are involved. Thanks to images obtained by functional magnetic resonance imaging, the researchers found that certain parts of the brains of obese children show alterations with respect to normal-weight or overweight children of the same age. The study findings were published in the journal