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Study sheds light on role of sleep-related brain activity in preventing Alzheimer's

Pennsylvania [US], June 2 (ANI): The evidence of sleep-dependent low-frequency (<0.1 Hz) global brain activity in the clearance of Alzheimer's disease-related toxin buildup, has been discovered by a team of researchers from The Pennsylvania State University. ....

Pennsylvania State University , United States , Xiao Liu , Alzheimer Disease Neuroimaging Initiative , Pennsylvania State , Disease Neuroimaging Initiative , Neurodegenerative Diseases , Alzheimer 39 S , Euroimaging Initiative Project , Myloid B , Latest Science Related Study , பென்சில்வேனியா நிலை பல்கலைக்கழகம் , ஒன்றுபட்டது மாநிலங்களில் , கிஷியஓ லியூ , முதுமறதி நோய் நியூரோஇமேஜிங் முயற்சி , பென்சில்வேனியா நிலை , நோய் நியூரோஇமேஜிங் முயற்சி ,

Coupled brain activity, cerebrospinal fluid flow could indicate Alzheimer's risk

Penn State researchers have found that the signal of global brain activity is coupled to movement of cerebral spinal fluid in humans. It appears that the coupled movement cleans out the brain’s toxins as a person sleeps. The weaker the coupled movement, the higher the risk the person could develop Alzheimer’s disease. The signal can viewed via non-invasive brain imaging and could serve as a clinical marker to help in diagnosis.
Penn State College of Engineering
First described in 2012, the glymphatic system acts as a waste management system, washing out the proteins and other buildup that can hinder brain activity. The critical component of the system is the cerebrospinal fluid flow, according to Liu, which his research suggests is activated by the global BOLD signal activation. In sleep, the glymphatic system can speed up its cleaning processes significantly. ....

United States , Feng Han , Yameng Gu , Jing Chen , Orfeum Buxton , Aaron Belkin Rosen , Xiao Liu , College Of The Liberal Arts , Human Development , Institute Of Computational , Penn State College Of Engineering , College Of Health , Alzheimer Disease Neuroimaging Initiative , Population Research Institute , Department Of Defense , National Institutes Of Health , Department Of Biomedical Engineering , White House Brain Research , Society Collaboratory At Penn , Elizabeth Fenton Susman Professor Of Biobehavioral Health , Data Sciences , Penn State , Biomedical Engineering , State College , Elizabeth Fenton Susman Professor , Biobehavioral Health ,

Role of sleep-related brain activity in clearing toxic proteins and preventing Alzheimer's disease

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IMAGE: The global brain signal in Alzheimer s disease patients is associated with weaker cerebrospinal fluid flow as compared with healthy controls
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Credit: Feng Han and Xiao Liu @ The Pennsylvania State University
Evidence of sleep-dependent low-frequency (PLOS Biology by Xiao Liu and colleagues at The Pennsylvania State University. This neuronal activity was more strongly linked with cerebrospinal fluid flow in healthy controls than higher risk groups and patients, and the findings could serve as a potential imaging marker for clinicians in evaluating patients.
The development of Alzheimer s disease is believed to be driven by the buildup of the toxic proteins amyloid-β and tau in the brain. The brain s glymphatic system plays a crucial role in clearing these toxins and previous work has shown a possible relationship between sleep-dependent global brain activity and the glymphatic system by showing this activity is coupled by cer ....

University Of Southern California , United States , South Korea , Xiao Liu , Eli Lilly , Michael Weiner , Foundation For The National Institutes Of Health , Department Of Defense , Neurorx Research , Meso Scale Diagnostics , National Institute Of Biomedical Imaging , Merck Co Inc , Pfizer Inc , Laboratory For Neuro Imaging , York University , Roche Ltd , Elan Pharmaceuticals Inc , Transition Therapeutics , Alzheimer Disease Neuroimaging Initiative , Eisai Inc , Pennsylvania State University , Boston University , Canadian Institutes Of Health Research , National Institutes Of Health Grant , Johnson Pharmaceutical Research Development , Northern California Institute For Research ,

Simple Tool Predicts Individual Alzheimer's Risk

Blood and quick cognitive tests boost accuracy to 90% ....

Judy George , Sebastian Palmqvist , Oskar Hansson , Lund University , Alzheimer Disease Neuroimaging Initiative , Mini Mental State Examination , Disease Neuroimaging Initiative , Medpage Today , Alzheimer 039s Disease , ஜூடி ஜார்ஜ் , லண்ட் பல்கலைக்கழகம் , முதுமறதி நோய் நியூரோஇமேஜிங் முயற்சி , மினி மன நிலை தேர்வு , நோய் நியூரோஇமேஜிங் முயற்சி ,

High blood cholesterol might speed up development of dementia

High blood cholesterol might speed up development of dementia
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United States , United Kingdom , Madhav Thambisetty , Vijay Varma , Alzheimer Disease Neuroimaging Initiative , National Institute On , Laboratory Of Behavioral Neuroscience , National Institute , Baltimore Longitudinal Study , Disease Neuroimaging Initiative , Translational Neuroscience , Drug Repurposing , Effective Alzheimer , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , விஜய் வர்மா , முதுமறதி நோய் நியூரோஇமேஜிங் முயற்சி , தேசிய நிறுவனம் ஆன் , ஆய்வகம் ஆஃப் நடத்தை நரம்பியல் , தேசிய நிறுவனம் , பால்டிமோர் நீளமான படிப்பு , நோய் நியூரோஇமேஜிங் முயற்சி , மொழிபெயர்ப்பு நரம்பியல் , மருந்து மறுபயன்பாடு , பயனுள்ள முதுமறதி ,