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Penn State researchers have found that the signal of global brain activity is coupled to movement of cerebral spinal fluid in humans. It appears that the coupled movement cleans out the brain’s toxins as a person sleeps. The weaker the coupled movement, the higher the risk the person could develop Alzheimer’s disease. The signal can viewed via non-invasive brain imaging and could serve as a clinical marker to help in diagnosis.
Penn State College of Engineering
First described in 2012, the glymphatic system acts as a waste management system, washing out the proteins and other buildup that can hinder brain activity. The critical component of the system is the cerebrospinal fluid flow, according to Liu, which his research suggests is activated by the global BOLD signal activation. In sleep, the glymphatic system can speed up its cleaning processes significantly.  ....

United States , Feng Han , Yameng Gu , Jing Chen , Orfeum Buxton , Aaron Belkin Rosen , Xiao Liu , College Of The Liberal Arts , Human Development , Institute Of Computational , Penn State College Of Engineering , College Of Health , Alzheimer Disease Neuroimaging Initiative , Population Research Institute , Department Of Defense , National Institutes Of Health , Department Of Biomedical Engineering , White House Brain Research , Society Collaboratory At Penn , Elizabeth Fenton Susman Professor Of Biobehavioral Health , Data Sciences , Penn State , Biomedical Engineering , State College , Elizabeth Fenton Susman Professor , Biobehavioral Health ,