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A research team of pharmacists at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2 coronavirus. The drug candidates are able to switch off the the key enzyme of the virus, the so-called main protease. ....
Loss of functions in the PLD1 gene causes congenital heart disease A team of researchers co-led by Michael Frohman, MD, PhD, of Stony Brook University, has identified an important cause of congenital heart disease. They discovered that certain loss of functions in the PLD1 (Phospholipase D1) gene causes congenital right-sided cardiac valve defects and neonatal cardiomyopathy. Their findings are detailed in a paper published early online in the Journal of Clinical Investigation. Congenital heart disease is the most common type of birth defect, accounting for one-third of all congenital anomalies with a worldwide occurrence of seven per thousand births. The majority of these defects include abnormalities of valve formation. Right-sided congenital heart disease incudes abnormalities of the pulmonary and tricuspid valves. ....
A new study compares the pathogenicity and infectiousness of one such variant, the VOC 202012/01 (B.1.1.7 lineage) from the United Kingdom, with the globally dominant D614G mutation-carrying strains. ....
Researchers in the UK have shown that the increased transmissibility of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage B.1.1.7 that emerged in the UK during the coronavirus disease 2019 (COVID-19) pandemic does not appear to be the result of increased viral replication or immune escape. ....
New approach harnesses disease-causing proteins to combat cancer Over many decades now, traditional drug discovery methods have steadily improved at keeping diseases at bay and cancer in remission. And for the most part, it s worked well. But it hasn t worked perfectly. A lab on UNLV s campus has been a hub of activity in recent years, playing a significant role in a new realm of drug discovery -; one that could potentially provide a solution for patients who have run out of options. It s starting to get to the point where we ve kind of taken traditional drug discovery as far as we can, and we really need something new. ....