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Unveiling the role of Daam1 gene in intestinal stem cell fate decisions

Stem cells can differentiate to replace dead and damaged cells. But how do stem cells decide which type of cell to become in a given situation? ....

South Korea , Bon Kyoung Koo , Gabriele Colozza , Institute For Basic Science , Molecular Biotechnology , Austrian Academy , Basic Science , Science Advances , Genome Engineering , Cell Division , Embryonic Stem Cells , Stem Cells , Wnt Signalling ,

Study reveals structural insights into the elusive tankyrase protein that fuels bowel cancer

Scientists have revealed the inner workings of a key protein involved in a wide range of cellular processes – potentially paving the way for better and less toxic cancer drugs. ....

United Kingdom , City Of , Kristian Helin , Sebastian Guettler , Marianne Baker , Emily Henderson , Cancer Research United , Cancer Research United Kingdom , Institute Of Cancer Research , Research Information , Nobel Prize Winning , Cancer Research , Industry Focus , Professor Sebastian Guettler , Deputy Head , Structural Biology , Chief Executive , Research Information Manager , Cancer Research United Kingdom Funded , Bowel Cancer , Cancer Treatment , Cell Division , Neurodegenerative Diseases , Stem Cells , Wnt Signalling ,

Research shows how orderly regeneration is activated after injury

The phenomenon of regeneration was discovered over 200 years ago in the freshwater polyp Hydra. Until now, however, it was largely unclear how the orderly regeneration of lost tissues or organs is activated after injury. ....

Thomasw Holstein , Emily Henderson , Heidelberg University , Wound Healing , Embryonic Development , Wnt Signalling ,

Study could lead to the development of novel treatments for drug-resistant cancers

Study could lead to the development of novel treatments for drug-resistant cancers
ETC-159, a made-in-Singapore anti-cancer drug that is currently in early phase clinical trials for use in a subset of colorectal and gynecological cancers, could also prevent some tumors from resisting therapies by blocking a key DNA repair mechanism, researchers from Duke-NUS Medical School and the Agency for Science, Technology and Research (A STAR) in Singapore reported in the journal
EMBO Molecular Medicine.
Among the many therapies used to treat cancers, inhibitors of the enzyme poly (ADP ribose) polymerase (PARP) prevent cancer cells from repairing naturally occurring DNA damage, including unwanted/harmful breaks in the DNA. When too many breaks accumulate, the cell dies. ....

Ann Lee , David Virshup , Emily Henderson , Agency For Science , Experimental Drug Development Centre , Assistant Professor Babita Madan , Stem Cell Biology , Professor David Virshup , Dna Damage , Medical School , Stem Cells , Wnt Signalling , ஆண்டு லீ , எமிலி ஹென்டர்சன் , சோதனை மருந்து வளர்ச்சி மையம் , உதவியாளர் ப்ரொஃபெஸர் பாபிடா மதன் , தண்டு செல் உயிரியல் , டீயெநே சேதம் , மருத்துவ பள்ளி , தண்டு செல்கள் ,