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Compounds inhibiting main protease of COVID-19 discovered

4 Mar in 14:40
A research team at the University of Bonn, Germany, has used high-throughput screening to discover two families of active substances that can block the replication of the SARS-CoV-2 coronavirus.
According to the researchers, these drug candidates are able to switch off the key enzyme of the virus, the so-called main protease.
The study, published in the journal Angewandte Chemie, stated that the novel coronavirus relies on the main protease as a key enzyme.
The main protease is an extremely promising starting point for coronavirus drug research, said Professor Christa Müller, one of the lead researchers. If this enzyme is blocked, viral replication in the body’s cells is stopped. ....

Nordrhein Westfalen , Angewandte Chemie , University Of Bonn , Institute Of The University Bonn , Pharmaceutical Institute , னோற்ர்ேன் வெஸ்ட்ஃபாலன் , பல்கலைக்கழகம் ஆஃப் பொன் , நிறுவனம் ஆஃப் தி பல்கலைக்கழகம் பொன் , மருந்து நிறுவனம் ,

Researchers find drug compounds that can inhibit SARS-CoV-2 - The Hindu BusinessLine

March 04, 2021
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A team of researchers at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2 coronavirus.
According to the researchers, these drug candidates are able to switch off the key enzyme of the virus, the so-called main protease.
The study, published in the journal Angewandte Chemie, stated that the novel coronavirus relies on the main protease as a key enzyme.
“The main protease is an extremely promising starting point for coronavirus drug research,” says Prof. Dr. Christa E. Müller of the Pharmaceutical Institute at the University of Bonn.
She added: “If this enzyme is blocked, viral replication in the body’s cells is stopped.” ....

Nordrhein Westfalen , Angewandte Chemie , University Of Bonn , Institute Of The University Bonn , Pharmaceutical Institute , Corona Virus , Covid 19 , Sars Cov 2 , னோற்ர்ேன் வெஸ்ட்ஃபாலன் , பல்கலைக்கழகம் ஆஃப் பொன் , நிறுவனம் ஆஃப் தி பல்கலைக்கழகம் பொன் , மருந்து நிறுவனம் , சர்வதேச பரவல் , கொரோனா வைரஸ் ,

Researchers Find SARS-CoV-2 Inhibitors

© V. Namasivayam/Pharmazeutisches Institut/Uni Bonn
A research team of pharmacists at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2 coronavirus. The drug candidates are able to switch off the the key enzyme of the virus, the so-called main protease. The study is based on laboratory experiments. Extensive clinical trials are still required for their further development as therapeutic drugs. The results have now been published in the journal
In order for the SARS-CoV-2 coronavirus to replicate, it relies on the main protease as a key enzyme. The virus first has its genome translated from RNA into a large protein strand. The viral main protease then cuts this protein chain into smaller pieces, from which the new virus particles are formed. The main protease is an extremely promising starting point for coronavirus drug research, says professor Dr. Christa E. Müller of the Pharmaceutical Institute a ....

Nordrhein Westfalen , Vigneshwaran Namasivayam , Maria Zyulina , Phuong Vu , V Namasivayam Pharmazeutisches Institut , Julian Breidenbach , Miriam Diett , Katharina Sylvester , Ghazl Al Hamwi , Carina Lemke , Angewandte Chemie , University Of Bonn , Institute Of The University Bonn , Transdisciplinary Research Area Life , Researchers Find , Pharmaceutical Institute , Transdisciplinary Research Area , Laura Sch , Uni Bonn , னோற்ர்ேன் வெஸ்ட்ஃபாலன் , புோங்க் உ , ஜூலியன் ப்ரீடன்பாக் , காதரின சில்வெஸ்டர் , கரினா லெம்கீ , பல்கலைக்கழகம் ஆஃப் பொன் , நிறுவனம் ஆஃப் தி பல்கலைக்கழகம் பொன் ,

Team Discovers Drug Candidates That Can Stop SARS-CoV-2 Replication

Team Discovers Drug Candidates That Can Stop SARS-CoV-2 Replication
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Nordrhein Westfalen , Angewandte Chemie , University Of Bonn , Institute Of The University Bonn , Transdisciplinary Research Area Life , Pharmaceutical Institute , Transdisciplinary Research Area , னோற்ர்ேன் வெஸ்ட்ஃபாலன் , பல்கலைக்கழகம் ஆஃப் பொன் , நிறுவனம் ஆஃப் தி பல்கலைக்கழகம் பொன் , மருந்து நிறுவனம் ,

Researchers discover SARS-CoV-2 inhibitors

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IMAGE: with one of the newly developed inhibitors in the active centre. The individual domains of the protein are shown in different colours, the inhibitor in pink.
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Credit: © V. Namasivayam/Pharmazeutisches Institut/Uni Bonn
A research team of pharmacists at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2 coronavirus. The drug candidates are able to switch off the the key enzyme of the virus, the so-called main protease. The study is based on laboratory experiments. Extensive clinical trials are still required for their further development as therapeutic drugs. The results have now been published in the journal ....

Nordrhein Westfalen , Vigneshwaran Namasivayam , Katharina Sylvester , Dominik Thimm , Ghazl Al Hamwi , Christin Vielmuth , Jochen Bodem , Vittoria Lopez , Salahuddin Mirza , Thanigaimalai Pillaiyar , Carina Lemke , Angewandte Chemie , Robin Gedschold , Maria Zyulina , Phuong Vu , Julian Breidenbach , Miriam Diett , Nina Geiger , Pharmazeutisches Institut , Ankec Schiedel , Institute Of Virology , University Of Bonn , Institute Of The University Bonn , Transdisciplinary Research Area Life , Pharmaceutical Institute , Transdisciplinary Research Area ,