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Loss of functions in the PLD1 gene causes congenital heart disease


Loss of functions in the PLD1 gene causes congenital heart disease
A team of researchers co-led by Michael Frohman, MD, PhD, of Stony Brook University, has identified an important cause of congenital heart disease. They discovered that certain loss of functions in the PLD1 (Phospholipase D1) gene causes congenital right-sided cardiac valve defects and neonatal cardiomyopathy. Their findings are detailed in a paper published early online in the
Journal of Clinical Investigation.
Congenital heart disease is the most common type of birth defect, accounting for one-third of all congenital anomalies with a worldwide occurrence of seven per thousand births. The majority of these defects include abnormalities of valve formation. Right-sided congenital heart disease incudes abnormalities of the pulmonary and tricuspid valves. ....

Noord Holland , Michael Frohman , Christian Salazar , Connie Bezzina , Ashkenazi Jews , Emily Henderson , Michael Airola , Najim Lahrouchi , Forrest Bowling , Renaissance School Of Medicine , Stony Brook University , Department Of Pharmacological Sciences , Study Co , University Of Amsterdam , Department Of Biochemistry , Study Co Senior Author , Pharmacological Sciences , Renaissance School , Distinguished Professor , Stony Brook , Cell Biology , Nature Chemical , Congenital Heart Disease , Heart Disease , நூற்த் ஹாலண்ட் , மைக்கேல் ப்ரோஹ்மான் ,

New approach harnesses disease-causing proteins to combat cancer


New approach harnesses disease-causing proteins to combat cancer
Over many decades now, traditional drug discovery methods have steadily improved at keeping diseases at bay and cancer in remission. And for the most part, it s worked well.
But it hasn t worked perfectly.
A lab on UNLV s campus has been a hub of activity in recent years, playing a significant role in a new realm of drug discovery -; one that could potentially provide a solution for patients who have run out of options.
It s starting to get to the point where we ve kind of taken traditional drug discovery as far as we can, and we really need something new. ....

Gary Kleiger , Ray Deshaies , Emily Henderson , Brenda Schulman Max Planck Institute Of Biochemistry , California Institute Of Technology , Max Planck Institute Of Biochemistry , University Of Nevada Las Vegas , Nevada Las , Brenda Schulman , Max Planck Institute , California Institute , Craig Crews , Allegiant Stadium , Drug Discovery , Ubiquitin Ligase , ராய் தேஷாய்ஸ் , எமிலி ஹென்டர்சன் , கலிஃபோர்னியா நிறுவனம் ஆஃப் தொழில்நுட்பம் , பல்கலைக்கழகம் ஆஃப் நெவாடா லாஸ் வேகாஸ் , நெவாடா லாஸ் , பிரெண்டா ஸ்சுழ்மான் , கலிஃபோர்னியா நிறுவனம் , கிரேக் குழுக்கள் , விசுவாசம் அரங்கம் , உயிர் வேதியியல் , மருந்து கண்டுபிடிப்பு ,