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Overcoming a newly recognized form of resistance to modern prostate cancer drugs

Overcoming a newly recognized form of resistance to modern prostate cancer drugs
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FDA to ban menthol cigarettes: U-M experts available

FDA to ban menthol cigarettes: U-M experts available
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Researchers develop first-in-class inhibitors against key leukemia protein

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IMAGE: An X-ray crystallography image showing an ASH1L inhibitor developed at U-M in complex with the protein.
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Credit: Grembecka / Cierpicki Labs
The protein made by the ASH1L gene plays a key role in the development of acute leukemia, along with other diseases. The ASH1L protein, however, has been challenging to target therapeutically.
Now a team of researchers led by Jolanta Grembecka, Ph.D., and Tomasz Cierpicki, Ph.D., from the University of Michigan has developed first-in-class small molecules to inhibit ASH1L s SET domain preventing critical molecular interactions in the development and progression of leukemia. ....

United States , Tomasz Cierpicki , Jolanta Grembecka , Nature Communications , Um Rogel Cancer Center , University Of Michigan , Michigan Medicine , Um Rogel Cancer , ஒன்றுபட்டது மாநிலங்களில் , இயற்கை தகவல்தொடர்புகள் , உம் ரோஜல் புற்றுநோய் மையம் , பல்கலைக்கழகம் ஆஃப் மிச்சிகன் , மிச்சிகன் மருந்து , உம் ரோஜல் புற்றுநோய் ,

FDA to ban menthol cigarettes: U-M experts available

EXPERTS ADVISORY
The FDA has announced that it will ban menthol cigarettes and flavored cigars within the next year, a move the tobacco industry has pushed against for the last decade. University of Michigan experts can comment.
David Mendez
Thuy Le of the Department of Health Management and Policy at the School of Public Health recently authored a study showing that menthol cigarettes contributed to 378,000 premature deaths in the United States between 1980 and 2018.
“Successful implementation of the FDA’s proposed ban on menthol cigarettes has the potential to save hundreds of thousands of lives over a short period and reduce health inequalities, particularly for African Americans,” Mendez said. “While menthol cigarettes were responsible for around 380,000 premature deaths in the U.S. over the last four decades, a disproportionately large number of those deaths occurred among the African American population.” ....

United States , Ross School Of Business , Thuy Le , David Mendez , Erik Gordon , Rafael Meza , Ken Warner , Um Ross School Of Business , Avedis Donabedian Distinguished University Professor , Department Of Health Management , School Of Public Health , University Of Michigan , Prevention Program , Um Rogel Cancer Center , Department Of Epidemiology , Health Management , Public Health , African American , Dean Emeritus , Cancer Epidemiology , Um Rogel Cancer , Um Ross School , ஒன்றுபட்டது மாநிலங்களில் , ஆஸ் பள்ளி ஆஃப் வணிக , த்ுய் லெ , டேவிட் மெண்டெஸ் ,

New clues to classic cancer target found in immune cells

New clues to classic cancer target found in immune cells
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