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New Approach Allows Researchers To Hit "Undruggable" Cancer Target

A protein degrader shows potential in targeting STAT5, a protein involved in leukemia and other forms of cancer. For decades, researchers have been interested in targeting the protein STAT5 in the fight against cancer. However, despite extensive efforts, STAT5 was eventually considered "undruggable ....

United States , Hoda Metwally , Shaomeng Wang , Renqi Xu , Atsunori Kaneshige , Donna Mceachern , Femi Wang , Meilin Wang , Yu Wang , Duxin Sun , Jenniferl Meagher , Wei Jiang , Jeannea Stuckey , Proteovant Roivant , Longchuan Bai , Hui Jiang , Pauld Kirchhoff , Bo Wen , Lijie Zhao , Michigan Technology Tri , University Of Michigan , Us Department Of Energy , Rogel Cancer Center Shared Resources , Wang Lab Michigan Medicine , National Cancer Institute , University Of Michigan Rogel Cancer Center ,

Protein degradation approach can be used to hit an 'undruggable' target against cancer

The protein STAT5 has long been an appealing target against cancer, but after decades of research it was consigned to the "undruggable" category. ....

United States , Shaomeng Wang , Emily Henderson , University Of Michigan Rogel Cancer Center , University Of Michigan , Michigan Rogel Cancer Center , Parke Davis Professor , Nature Chemical , Cancer Treatment ,

THE PROSTATE CANCER FOUNDATION ANNOUNCES INAUGURAL $30 MILLION TACTICAL AWARDS PROGRAM FOR INNOVATIVE PROSTATE CANCER RESEARCH

/PRNewswire/ The Prostate Cancer Foundation (PCF) today announced four inaugural Class of 2022 TACTICAL (Therapy ACceleration To Intercept CAncer Lethality). ....

United Kingdom , Yu Chen , United States , University Of Southern California , University Of Pennsylvania , Yi Xing , University Of California San Francisco , San Francisco , James Gulley , Salomon Tendler , Anna Pacelli , Michael Hofman , Christine Mona , Ken Herrmann , Alex Tsodikov , Stacil Vernick , Arul Chinnaiyan , Shahneen Sandhu , Felix Feng , Sarah Fenton , John Maris , Joshi Alumkal , Nikolaous Sgourakis , Scott Norberg , Wolfgang Fendler , Peter Choyke ,

This molecule could be behind liver fibrosis

This molecule could be behind liver fibrosis
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Louisg Dalecy , Suthat Liangpunsakul , Annas Lok , Chong Shen , Zhiguo Zhang , Liang Sheng , M Bishr Omary , Xiao Zhong , Liangyou Rui , Shaomeng Wang , Nature Communications , School Department Of Molecular Integrative Physiology , Non Alcoholic Steatohepatitis , Alecy Collegiate Professor , Um Medical School Department ,

Ascentage Pharma International : The Journal of Medicinal Chemistry Publishes Study Showing Potential of the Potent EED Inhibitor EEDi-5273 (APG-5918) to Achieve Complete Tumor Regression by Modulating the Epigenetics

SUZHOU, China, and ROCKVILLE, Md., Oct. 18, 2021 /PRNewswire/ Ascentage Pharma , a global biopharmaceutical company engaged in developing novel therapies for cancers, chronic hepatitis B , and. | October 18, 2021 ....

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