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Overcoming a newly recognized form of resistance to modern prostate cancer drugs

Overcoming a newly recognized form of resistance to modern prostate cancer drugs
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United States , San Francisco , Sanjay Lakhotia , Chao Zhang , Wayned Kuni , Williamk Storck , Anbarasu Kumaraswamy , Felixy Feng , Evas Rodansky , Duanchen Sun , Xiangnan Guan , Sarah Attwell , Chelsea Jenkins , Himisha Beltran , Rahul Aggarwal , Zheng Xia , Colm Morrissey , Joshi Alumkal , Markp Labrecque , David Sampson , Joshuaa Urrutia , Jonathanz Sexton , Emilym Gesner , Joela Yates , Danielj Coleman , Katherine Welker Leng ,

Prostate Cancer: Multigene Biomarker Validated as Prognostic/Predictive Test


Feb 15, 2021
Genomic classifier helps weed out men less likely to benefit from added hormone Tx
To help clinicians determine which men with recurrent prostate cancer after surgery will benefit from the addition of hormone therapy to salvage radiotherapy (sRT), researchers validated the Decipher genomic classifier, demonstrating that it was independently associated with the risk of distant metastases (DM), prostate cancer-specific mortality (PCSM), and overall survival (OS).
Importantly, these results suggest that not all men with biochemically recurrent prostate cancer will derive the same benefits from the addition of hormone therapy to sRT.
“To date and to our knowledge, no multigene expression biomarker has been rigorously validated as a prognostic or predictive test in patients with prostate cancer who are receiving radical therapy,” Felix Y. Feng, MD, of the Helen Diller Family Comprehensive Cancer Center, San Francisco, and colleagues observed. “[These] ....

United States , San Francisco , Ppam Harrison , Felixy Feng , Seane Mcguire , National Cancer Institute , University Of Texas Md Anderson Cancer Center , Helen Diller Family Comprehensive Cancer Center , Cancer Center , Contributing Writer , National Cancer , ஒன்றுபட்டது மாநிலங்களில் , சான் பிரான்சிஸ்கோ , பாம் ஹாரிசன் , தேசிய புற்றுநோய் நிறுவனம் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , ஹெலன் டில்லர் குடும்பம் விரிவான புற்றுநோய் மையம் , புற்றுநோய் மையம் , தேசிய புற்றுநோய் ,

Decipher Test May Guide Post-Surgical Tx in Prostate Cancer


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Scores with the 22-gene Decipher genomic classifier (GC) were independently associated with risk for metastasis, prostate cancer-specific mortality, and overall survival among men with recurrent prostate cancer treated with salvage radiotherapy with or without bicalutamide.
These results suggest that not all men with biochemically recurrent disease after surgery will benefit from hormone therapy, reported Felix Y. Feng, MD, of the University of California San Francisco, and colleagues in
Using specimens from the phase III NRG/RTOG9601 clinical trial, Feng and colleagues generated GC scores from 352 patients with median follow-up of 13 years. Patient GC scores were calculated on a continuous scale from 0 (lowest) to 1 (highest). Scores were then classified as low (42%), intermediate (38%), or high (20%) using previously established 0.45 and 0.60 as cutoffs. ....

United States , Felixy Feng , Seane Mcguire , American Society Of Clinical Oncology , University Of Texas Md Anderson Cancer Center , University Of California San Francisco , California San Francisco , Cancer Center , American Society , Clinical Oncology , Carcinoma Of Prostate , Malignant Tumor Of Prostate , ஒன்றுபட்டது மாநிலங்களில் , அமெரிக்கன் சமூகம் ஆஃப் மருத்துவ புற்றுநோயியல் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் பிரான்சிஸ்கோ , கலிஃபோர்னியா சான் பிரான்சிஸ்கோ , புற்றுநோய் மையம் , அமெரிக்கன் சமூகம் , மருத்துவ புற்றுநோயியல் , புற்றுநோய் ஆஃப் ப்ராஸ்டேட் , வீரியம் மிக்கது கட்டி ஆஃப் ப்ராஸ்டேட் ,