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Medicines trigger immune cells to attack prostate cancer miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.
UCSF Cancer Specialists to Present Clinical Findings at Major Conference miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.
Overcoming a newly recognized form of resistance to modern prostate cancer drugs eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.
Feb 15, 2021 Genomic classifier helps weed out men less likely to benefit from added hormone Tx To help clinicians determine which men with recurrent prostate cancer after surgery will benefit from the addition of hormone therapy to salvage radiotherapy (sRT), researchers validated the Decipher genomic classifier, demonstrating that it was independently associated with the risk of distant metastases (DM), prostate cancer-specific mortality (PCSM), and overall survival (OS). Importantly, these results suggest that not all men with biochemically recurrent prostate cancer will derive the same benefits from the addition of hormone therapy to sRT. “To date and to our knowledge, no multigene expression biomarker has been rigorously validated as a prognostic or predictive test in patients with prostate cancer who are receiving radical therapy,” Felix Y. Feng, MD, of the Helen Diller Family Comprehensive Cancer Center, San Francisco, and colleagues observed. “[These] ....
email article Scores with the 22-gene Decipher genomic classifier (GC) were independently associated with risk for metastasis, prostate cancer-specific mortality, and overall survival among men with recurrent prostate cancer treated with salvage radiotherapy with or without bicalutamide. These results suggest that not all men with biochemically recurrent disease after surgery will benefit from hormone therapy, reported Felix Y. Feng, MD, of the University of California San Francisco, and colleagues in Using specimens from the phase III NRG/RTOG9601 clinical trial, Feng and colleagues generated GC scores from 352 patients with median follow-up of 13 years. Patient GC scores were calculated on a continuous scale from 0 (lowest) to 1 (highest). Scores were then classified as low (42%), intermediate (38%), or high (20%) using previously established 0.45 and 0.60 as cutoffs. ....