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Highly ambitious and unachievable, analyst says as PAS eyes Selangor

“With the current electoral map, Perikatan Nasional or PAS couldn’t win the state (in the 2023 state election). I have huge reservations about their ability to win with the addition of new (mixed) seats”
(FMT) - An analyst has questioned the odds of PAS taking over Selangor in the next general ele ....

Kuala Selangor , Kuala Langat , Malaysia General , Sabak Bernam , Perikatan Nasional , Universiti Teknologi Mara , Pakatan Rakyat , Zurk Ahmad , Mazlan Ali , Hulu Selangor , International Islamic University Malaysia , Zhe Wei , Pakatan Harapan , Malay Muslims ,

Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis


Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis
In a new study published in
Circulation Research, Chen-Yu Zhang and Xiaohong Jiang s group from Nanjing University and Dongjin Wang s group from Nanjing Drum Tower Hospital reported a critical role of PGC1α in maintaining the contractile phenotype of vascular smooth muscle cells (VSMCs) and highlighted the therapeutic potential of PGC1α for atherosclerosis.
The traditional view holds that aberrant proliferation of VSMCs promotes plaque formation after vessel injury and inflammation, whereas the presence of VSMCs in the fibrous cap of the plaque is beneficial.
Although it has long been assumed that these seemingly contradictory functions of VSMCs during atherosclerosis arise from their remarkable plasticity, direct evidence that VSMCs undergo phenotypic switching during atherogenesis in vivo has only been proven recently by rigorous lineage tracing studies. ....

Jing Li , Xi Chen , Yuhang Tang , Yanteng Shi , Jinhong Xu , Le Cui , Chen Yu Zhang , Emily Henderson , Yunxing Xue , Xiaohong Jiang , Haoquan Wang , George Liu , Dongjin Wang , Hoshun Chong , Yujing Zhang , Jutang Li , Circulation Research , Nanjing University , Nanjing Drum Tower Hospital , Zhe Wei , ஜிங் லி , க்ஷி சென் , சென் யூ ஜாங் , எமிலி ஹென்டர்சன் , ஜார்ஜ் லியூ , சுழற்சி ஆராய்ச்சி ,