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Why elderly, diabetic are at higher risk of COVID infection

Low levels of microRNA (miRNA) immunity increase the risk of COVID-19 infection in older adults and people with diabetes, according to Nanjing University researchers.

Chen yu zhangSchool of life sciencesNanjing universitySignal transductionTargeted therapyCovid 19Covid 19Ars cov 2Covid diabetesOld peopleசென் யூ ஜாங்பள்ளி ஆஃப் வாழ்க்கை அறிவியல்நான்ஜிங் பல்கலைக்கழகம்சமிக்ஞை கடத்தல்இலக்கு சிகிச்சை

Why elderly, diabetic are at higher risk of Covid infection

Researchers have identified that low microRNA (miRNA) immunity increases the risk of Covid-19 infection in older adults and people with diabetes.MicroRNAs are a key class of gene expression regulators which play an important role in .

Chen yu zhangSchool of life sciencesNanjing universitySignal transductionTargeted therapyசென் யூ ஜாங்பள்ளி ஆஃப் வாழ்க்கை அறிவியல்நான்ஜிங் பல்கலைக்கழகம்சமிக்ஞை கடத்தல்இலக்கு சிகிச்சை

Deficient RNA immunity cause higher risk of Covid infection in elderly people and diabetic patients

In a new study, Chen-Yu Zhang's group from Nanjing University presents a rather striking finding that four circulating miRNAs, which are high in healthy.

Chen yu zhangNational basic research program of chinaNational natural science foundation of chinaResearch funds for the central universitiesNatural science foundation of jiangsu provinceTechnology major project of chinaNanjing universityChinese scienceTechnology major projectNational basic research programNational natural science foundationTraining programMajor research planNatural science foundationJiangsu provinceFundamental research funds

Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis

Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis In a new study published in Circulation Research, Chen-Yu Zhang and Xiaohong Jiang s group from Nanjing University and Dongjin Wang s group from Nanjing Drum Tower Hospital reported a critical role of PGC1α in maintaining the contractile phenotype of vascular smooth muscle cells (VSMCs) and highlighted the therapeutic potential of PGC1α for atherosclerosis. The traditional view holds that aberrant proliferation of VSMCs promotes plaque formation after vessel injury and inflammation, whereas the presence of VSMCs in the fibrous cap of the plaque is beneficial. Although it has long been assumed that these seemingly contradictory functions of VSMCs during atherosclerosis arise from their remarkable plasticity, direct evidence that VSMCs undergo phenotypic switching during atherogenesis in vivo has only been proven recently by rigorous lineage tracing studies.

Jing liXi chenYuhang tangYanteng shiJinhong xuLe cuiChen yu zhangEmily hendersonYunxing xueXiaohong jiangHaoquan wangGeorge liuDongjin wangHoshun chongYujing zhangJutang li

Smooth muscle overexpression of PGC1α attenuates atherosclerosis in rabbits

Smooth muscle overexpression of PGC1α attenuates atherosclerosis in rabbits
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Jing liXi chenYuhang tangYanteng shiJinhong xuLe cuiChen yu zhangYunxing xueXiaohong jiangHaoquan wangDongjin wangGeorge liuHoshun chongJutang liYujing zhangSchool of life sciences