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Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis In a new study published in Circulation Research, Chen-Yu Zhang and Xiaohong Jiang s group from Nanjing University and Dongjin Wang s group from Nanjing Drum Tower Hospital reported a critical role of PGC1α in maintaining the contractile phenotype of vascular smooth muscle cells (VSMCs) and highlighted the therapeutic potential of PGC1α for atherosclerosis. The traditional view holds that aberrant proliferation of VSMCs promotes plaque formation after vessel injury and inflammation, whereas the presence of VSMCs in the fibrous cap of the plaque is beneficial. Although it has long been assumed that these seemingly contradictory functions of VSMCs during atherosclerosis arise from their remarkable plasticity, direct evidence that VSMCs undergo phenotypic switching during atherogenesis in vivo has only been proven recently by rigorous lineage tracing studies. ....
Smooth muscle overexpression of PGC1α attenuates atherosclerosis in rabbits eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.
E-Mail IMAGE: The first measurement of hydroxide conductivity and comparison in anion conducting polymer thin films. (X = OH and Br) view more Credit: Yuki Nagao from JAIST Ishikawa, Japan - As decarbonization progresses rapidly in the world, fuel cells offer potentially higher electrical efficiency than conventional power-generating systems. Anion exchange membrane fuel cells offer advantages of using non-precious metal catalysts than proton exchange membrane fuel cells. One of the challenges of this next-generation fuel cell is to clarify the hydroxide ion conductivity in the ion conductive polymer around the electrode catalyst. The difficulty of studying the hydroxide ion conductivity at the electrode interface is that the hydroxide ion, which is a carrier, easily reacts with carbon dioxide in the air. To solve this problem, all evaluation devices were improved so that the sample did not come into contacting with air. ....