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Adenine methylation is very scarce in the drosophila genome and not erased by the Ten Eleven Translocation dioxygenase

Adenine methylation is very scarce in the drosophila genome and not erased by the Ten Eleven Translocation dioxygenase
elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.

United States , United Kingdom , Bioruptor Pico Diagenode , Bandelin Sonoplus , Tetrahydrouridine Merck Millipore , Ligue Nationale Contre Le , Pacific Biosciences , Agilent Masshunter , A Bochtler Fernandes , Boulias Greer , Sanchez Romero Casadesus , Alderman Xiao , Diagenode Megaruptor , Deutsche Forschungsgemeinschaft , Santa Clara , Wion Casadesus , Xu Bochtler , Krauss Reuter , A Boulias Greer , Jackson Immuno , Pacbio Smrtcells , Novogene Cambridge , Jeyaprakash Hoy , Developmental Study Hybridoma Bank , Drosophila Bloomington Stock Center , Library Prep Kit Illumina ,

Apoptotic stress causes mtDNA release during senescence and drives the SASP

Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP)1. Mitochondria are major regulators of the SASP; however, the underlying mechanisms have not been elucidated2. Mitochondria are often essential for apoptosis, a cell fate distinct from cellular senescence. During apoptosis, widespread mitochondrial outer membrane permeabilization (MOMP) commits a cell to die3. Here we find that MOMP occurring in a subset of mitochondria is a feature of cellular senescence. This process, called minority MOMP (miMOMP), requires BAX and BAK macropores enabling the release of mitochondrial DNA (mtDNA) into the cytosol. Cytosolic mtDNA in turn activates the cGAS–STING pathway, a major regulator of the SASP. We find that inhibition of MOMP in vivo decreases inflammatory markers and improves healthspan in aged mice. Our results reveal that apoptosis and senescence are regulated by similar mitochondria-depende ....

United Kingdom , Adooq Biosciences , Tocris Bioscience , Antifade Mountant , Gencode Grch , Bruker Ct , Rnalater Qiagen , Dynabeads Invitrogen , Skyscan Nrecon , Zeiss Airyscan , Octo Dissociator Miltenyi , Analysis Software , Imol Polish Academy Of Sciences , Huygens Deconvolution Software , University Of Glasgow Animal Welfare , Pall Corporation , Thermo Fisher , National Institute On Aging , United Kingdom Home Office , Thermo Fisher Scientific , Atlanta Biological , Absolute Human Mitochondrial , Number Quantification , Tissue Kit , Qiaquick Nucleotide Removal Kit , Agilent Seahorse ,

QIAGEN N.V.: QIAGEN enhances QIAwave portfolio with new eco-friendlier nucleic acid extraction kits

QIAGEN N.V.: QIAGEN enhances QIAwave portfolio with new eco-friendlier nucleic acid extraction kits
finanznachrichten.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from finanznachrichten.de Daily Mail and Mail on Sunday newspapers.

Baden Wüberg , Thomas Schweins , Life Sciences , Exchange Commission , Life Sciences Business Area , Research Specialist , Us Securities Exchange , University Of Pennsylvania , Frankfurt Prime Standard , Plus Mini Kit , Senior Vice President , Tissue Kit , Plasmid Miniprep Kit , Science Based Targets , Molecular Diagnostics , Exchange Act , Annual Report ,

QIAGEN enhances QIAwave portfolio with new eco-friendlier nucleic acid extraction kits

QIAGEN enhances QIAwave portfolio with new eco-friendlier nucleic acid extraction kits
tmcnet.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from tmcnet.com Daily Mail and Mail on Sunday newspapers.

Thomas Theuringer , Phoebe Loh , Daniela Berheide , Thomas Schweins , John Gilardi , Us Securities Exchange , Life Sciences Business Area , University Of Pennsylvania , Exchange Commission , Research Specialist , Life Sciences , Frankfurt Prime Standard , Plus Mini Kit , Senior Vice President , Tissue Kit , Plasmid Miniprep Kit , Science Based Targets , Molecular Diagnostics , Exchange Act , Annual Report ,

QIAGEN enhances QIAwave portfolio with new eco-friendlier nucleic acid extraction kits - Qiagen (NYSE:QGEN)

Venlo, the Netherlands, Sept. 25, 2023 (GLOBE NEWSWIRE) QIAGEN (NYSE:QGEN, Frankfurt Prime Standard: QIA)) today announced the extension of its eco-friendlier QIAwave product line with the addition of two new ....

John Gilardi , Daniela Berheide , Thomas Theuringer , Thomas Schweins , Phoebe Loh , Life Sciences , Us Securities Exchange , Research Specialist , Life Sciences Business Area , Exchange Commission , University Of Pennsylvania , Plus Mini Kit , Senior Vice President , Tissue Kit , Plasmid Miniprep Kit , Science Based Targets , Molecular Diagnostics , Exchange Act , Annual Report ,