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Scientists uncover key to enhancing cancer-killing T cells

T cells are the key immune system component involved in killing cancer. Tumors produce signals that turn off these T cells, partially by forcing them to progressively differentiate (mature) into a hypofunctional state known as exhaustion. ....

Jordy Saravia , Peipei Zhou , Shondra Pruett Miller , Hongbo Chi , Hongling Huang , Nicole Chapman , Jonp Connelly , Xiang Sun , Zhao Shi , Cancer Center Support Grant , National Institutes Of Health , Jude Children Research Hospital , Jude Department Of Immunology , Jude Children , Research Hospital , Jude Department , Sujing Yuan , Seon Ah Lim , National Institutes , T Cell , Bone Marrow , Ancer Immunotherapy , Chimeric Antigen Receptor , Ene Expression , Immune System , Transcription Factors ,

Immune and tumor cell 'tug-of-war' controls anti-cancer activity

Immune and tumor cell 'tug-of-war' controls anti-cancer activity
sciencedaily.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencedaily.com Daily Mail and Mail on Sunday newspapers.

Gustavo Palacios , Xiang Sun , Chuansheng Guo , Nicole Chapman , Sherri Rankin , Jordy Saravia , Yogesh Dhungana , Zhao Shi , Ryu Sun , Hongbo Chi , National Institutes Of Health , Jude Department Of Immunology , Jude Department , Zhiyuan You , Cliff Guy , Sujing Yuan , Seon Ah Lim , National Institutes ,

Immune and tumor cell "tug-of-war" controls a

Immune and tumor cell "tug-of-war" controls a
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Sherri Rankin , Chuansheng Guo , Zhao Shi , Nicole Chapman , Gustavo Palacios , Michael Sheffield , Ryu Sun , Xiang Sun , Jordy Saravia , Hongbo Chi , Yogesh Dhungana , National Cancer Comprehensive Center , Jude Department Of Immunology , Jude Children Research Hospital , National Institutes Of Health , Jude Children , Research Hospital , Jude Department , Zhiyuan You , Cliff Guy , Sujing Yuan , Seon Ah Lim , National Institutes , Jude Media Relations Contacts , Jude Progress ,

Pushing T cells down "memory lane" may improve cancer therapy

/PRNewswire/ Scientists at St. Jude Children s Research Hospital identified a molecular mechanism that in a preclinical study unlocked the promise of CAR. ....

Hongbo Chi , Jasont Yustein , Shondram Pruett Miller , Hongling Huang , Charles Wm Roberts , Swantje Liedmann , Dalia Haydar , Giedre Krenciute , Zhexin Zhu , Zhao Shi , Jonp Connelly , Christopher Derenzo , Piyush Sharma , Markj Chen , Mao Yang , Helen Beere , Yogesh Dhungana , Zhenrui Li , National Cancer Institute , National Institutes Of Health , Jude Department Of Immunology , Baylor College Of Medicine , Jude Department , Sujing Yuan , Jeremy Chase Crawford , Baylor College ,

Pushing T cells down "memory lane" may improve cancer therapy

Scientists at St. Jude Children s Research Hospital identified proteins that help decide T cell fate and used the finding to improve CAR-T cell th. ....

Doug Green , Hongbo Chi , Jasont Yustein , Shondram Pruett Miller , Hongling Huang , Charles Wm Roberts , Swantje Liedmann , Dalia Haydar , Giedre Krenciute , Zhexin Zhu , Zhao Shi , Jonp Connelly , Christopher Derenzo , Piyush Sharma , Markj Chen , Mao Yang , Helen Beere , Yogesh Dhungana , Zhenrui Li , National Cancer Institute , Jude Children Research Hospital , National Institutes Of Health , National Cancer Comprehensive Center , Jude Department Of Immunology , Baylor College Of Medicine , Jude Children ,