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 E-Mail IMAGE: The researchers analysed the contribution of the five main cell types involved in coronary artery disease. view more  Credit: UEF/Raija Törrönen Using single cell technology, a new study sheds light on the significance of genetic risk factors for, and the diversity of cells involved in, the development of coronary artery disease. The researchers analysed human atherosclerotic lesions to map the chromatin accessibility of more than 7,000 cells. The chromatin accessibility is known to reflect active regions and genes in the genome. The findings were published in Circulation Research. Genome-wide association studies of the human genome have identified over 200 loci associated with coronary artery disease. More than 90% of them are located outside protein-coding genes, in so called cis-regulatory elements, whose significance in the pathogenesis of coronary artery disease remains unclear.

United statesLandskapet birkalandSeppo ylMinna kaikkonenEuropean union horizonHerttuala university of eastern finlandAmerican heart associationAcademy researchAi virtanen institute for molecular sciencesCasey romanoski university of arizonaUniversity of eastern finlandUniversity of turkuAcademy of finlandEuropean research councilUs national institutes of healthMete civelek university of virginia