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15 Years of PLOS ONE - Author Perspectives

This month marks 15 years since PLOS ONE published its first papers. As we celebrate this milestone, we invited authors of some of the first papers to be published, as well as an author of a more recent paper, to share information about their careers, their perspectives on Open Science, and their experiences as PLOS ONE authors. ....

United States , United Kingdom , New Zealand , Primorskiy Kray , Landskapet Birkaland , Andreja Romanovsky , Ardem Patapoutian , Guillermo Branco , Seppo Yl , Andrei Ivanov , Camila Almeida , Nancyl Romanovsky , Matthewr Goddard , Catalina Pharma , Nicolasg Bazan , Alex Steiner , Matthew Goddard , David Julius , Andras Garami , Miriam Kolko , Zharko Pharma , Seppo Yla Herttuala , Matthew Goddard University Of Lincoln , Danish Ophthalmological Association , Academy Professor , University Of Copenhagen ,

Cell-type-specific insight into the function of risk factors in coronary artery disease


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IMAGE: The researchers analysed the contribution of the five main cell types involved in coronary artery disease.
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Credit: UEF/Raija Törrönen
Using single cell technology, a new study sheds light on the significance of genetic risk factors for, and the diversity of cells involved in, the development of coronary artery disease. The researchers analysed human atherosclerotic lesions to map the chromatin accessibility of more than 7,000 cells. The chromatin accessibility is known to reflect active regions and genes in the genome. The findings were published in
Circulation Research.
Genome-wide association studies of the human genome have identified over 200 loci associated with coronary artery disease. More than 90% of them are located outside protein-coding genes, in so called cis-regulatory elements, whose significance in the pathogenesis of coronary artery disease remains unclear. ....

United States , Landskapet Birkaland , Seppo Yl , Minna Kaikkonen , European Union Horizon , Herttuala University Of Eastern Finland , American Heart Association , Academy Research , Ai Virtanen Institute For Molecular Sciences , Casey Romanoski University Of Arizona , University Of Eastern Finland , University Of Turku , Academy Of Finland , European Research Council , Us National Institutes Of Health , Mete Civelek University Of Virginia , Circulation Research , Cardiovascular Genomics , Associate Professor Minna Kaikkonen M , Eastern Finland , Mete Civelek , Casey Romanoski , European Union , Sigrid Jus , Research Fellow , Molecular Sciences ,

Nasal vaccines: The way forward to tackle COVID-19?