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E-Mail IMAGE: The researchers analysed the contribution of the five main cell types involved in coronary artery disease. view more Credit: UEF/Raija Törrönen Using single cell technology, a new study sheds light on the significance of genetic risk factors for, and the diversity of cells involved in, the development of coronary artery disease. The researchers analysed human atherosclerotic lesions to map the chromatin accessibility of more than 7,000 cells. The chromatin accessibility is known to reflect active regions and genes in the genome. The findings were published in Circulation Research. Genome-wide association studies of the human genome have identified over 200 loci associated with coronary artery disease. More than 90% of them are located outside protein-coding genes, in so called cis-regulatory elements, whose significance in the pathogenesis of coronary artery disease remains unclear. ....
Study Finds Breast Cancer's Response to Tumor Stiffness May Predict Bone Metastasis arizona.edu - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from arizona.edu Daily Mail and Mail on Sunday newspapers.
Breast cancer's response to tumour stiffness might help predict bone metastasis aninews.in - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from aninews.in Daily Mail and Mail on Sunday newspapers.
Response to tumour stiffness helps in bone metastasis phoenixherald.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from phoenixherald.com Daily Mail and Mail on Sunday newspapers.
Study finds breast cancer s response to tumour stiffness may predict bone metastasis ANI | Updated: Jul 01, 2021 07:58 IST Washington [US], July 1 (ANI): A new study by University of Arizona Health Sciences researchers found that cancer cells become more aggressive when exposed to tissue stiffening and that these changes persist over time. The paper, Breast tumour stiffness instructs bone metastasis via maintenance of mechanical conditioning , published in the journal Cell Reports, found that the stiffness of the breast tumour microenvironment can cause changes to cancer cells that make them more aggressively spread to the bone. Tumour stiffening, which develops as diseased breast tissue becomes fibrotic, plays a major role in how breast cancer cells spread throughout the body. ....