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"Molecular interactions of STAC proteins with skeletal muscle dihydropy" by Dmitry Shishmarev, Emily Rowland et al.

Excitation-contraction coupling (ECC) is the physiological process in which an electrical signal originating from the central nervous system is converted into muscle contraction. In skeletal muscle tissue, the key step in the molecular mechanism of ECC initiated by the muscle action potential is the cooperation between two Ca2+ channels, dihydropyridine receptor (DHPR; voltage-dependent L-type calcium channel) and ryanodine receptor 1 (RyR1). These two channels were originally postulated to communicate with each other via direct mechanical interactions; however, the molecular details of this cooperation have remained ambiguous. Recently, it has been proposed that one or more supporting proteins are in fact required for communication of DHPR with RyR1 during the ECC process. One such protein that is increasingly believed to play a role in this interaction is the SH3 and cysteine-rich domain-containing protein 3 (STAC3), which has been proposed to bind a cytosolic portion of the DHPR α1 ....

Xcitation Contraction Coupling , I Iii Loop , Rotein Protein Interactions , Skeletal Muscle ,

Probing how proteins pair up inside cells

Biologists designed a screening method to understand how short stretches of amino acids short linear motifs (SLiMs) selectively bind to certain proteins, and distinguish between binding partners with similar structures. ....

Amy Keating , Ylva Ivarsson , Uppsala University , Theresa Hwang Phd , Theresa Hwang , Amy Keating , Protein Research , Short Linear Motifs , Ylva Ivarsson , Rotein Protein Interactions , Protein Binding ,