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Probing how proteins pair up inside cells

Biologists designed a screening method to understand how short stretches of amino acids short linear motifs (SLiMs) selectively bind to certain proteins, and distinguish between binding partners with similar structures. ....

Amy Keating , Ylva Ivarsson , Uppsala University , Theresa Hwang Phd , Theresa Hwang , Amy Keating , Protein Research , Short Linear Motifs , Ylva Ivarsson , Rotein Protein Interactions , Protein Binding ,

Scientists identify missing molecular links to SARS-CoV-2, host interactions

February 15, 2021 Researchers have identified interactions between short viral proteins and receptors that facilitate the entry of the SARS-CoV-2 virus into a host. This evidence of molecular links, published in
Science Signaling on February 12, may help scientists identify drugs that are highly effective at blocking the virus.
SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) as a receptor to attach to host cells. ACE2 is a single-pass type I membrane protein with a short cytosolic C-terminal region. While SARS-CoV-2 primarily binds to ACE2 in the lungs, previous studies have revealed that there is very little ACE2 gene expression in normal lungs, suggesting that the ACE2 receptor is insufficient on its own to establish severe lung disease. ....

Buenos Aires , Distrito Federal , Manjeet Kumar , Rayne Zaayman , University College Dublin , European Molecular Biology Laboratory , Science Signaling , Universidad Nacional De San Mart , Src Homology , Sars Cov 2 , Rgd Motif , Short Linear Motifs , Host Receptors , Viral Entry , Cell Attachment , Host Directed Therapies , புஏனோஸ் ஐரிஸ் , திஸ்திரிதோ கூட்டாட்சியின் , மன்ஜீத் குமார் , பல்கலைக்கழகம் கல்லூரி டப்ளின் , ஐரோப்பிய மூலக்கூறு உயிரியல் ஆய்வகம் , அறிவியல் சமிக்ஞை , யுனிவர்சிடாட் நேஸீயநல் டி சான் மார்ட் , ர்கட் மையக்கருத்து , குறுகிய நேரியல் கருக்கள் , வைரஸ் நுழைவு ,