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A novel antidiuretic hormone governs tumour-induced renal dysfunction

Maintenance of renal function and fluid transport are essential for vertebrates and invertebrates to adapt to physiological and pathological challenges. Human patients with malignant tumours frequently develop detrimental renal dysfunction and oliguria, and previous studies suggest the involvement of chemotherapeutic toxicity and tumour-associated inflammation1,2. However, how tumours might directly modulate renal functions remains largely unclear. Here, using conserved tumour models in Drosophila melanogaster3, we characterized isoform F of ion transport peptide (ITPF) as a fly antidiuretic hormone that is secreted by a subset of yki3SA gut tumour cells, impairs renal function and causes severe abdomen bloating and fluid accumulation. Mechanistically, tumour-derived ITPF targets the G-protein-coupled receptor TkR99D in stellate cells of Malpighian tubules—an excretory organ that is equivalent to renal tubules4—to activate nitric oxide synthase–cGMP signalling and inh ....

Al Dhaheri , Cell Biol , Cachexia Sarcopenia Muscle , Drosophila Malpighian , Cell Differ , Cell Atlas , Drosophilag Protein Coupled , Cell Rep , Model Mech ,

Sengenics' protein array to explore protein-protein interactions

This article outlines the study of protein-protein interaction that affects protein function using Sengenics protein array. ....

United States , Maria Osipova , Sponsored Content , Biotin Carboxyl Carrier Protein , Sengenics Protein Array , Image Credit , Model Mech , North America , Content Policy , News Medical Net , Rotein Protein Interactions ,

Early Th2 inflammation in the upper respiratory mucosa as a predictor of severe COVID-19 and modulation by early treatment with inhaled corticosteroids: a mechanistic analysis

Early Th2 inflammation in the upper respiratory mucosa as a predictor of severe COVID-19 and modulation by early treatment with inhaled corticosteroids: a mechanistic analysis
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United States , United Kingdom , Western Australia , City Of , Astrazeneca Gothenburg , Sanchez Sevilla Uruchurtu , Nicolau Jr , United Kingdom National Health Service , University Of Oxford , Fulham London Research Ethics Committee , Boehringer Ingelheim , National Health Research Authority , Australian Government Research Training Program , Department Of Health , Biomedical Research Centre , Albus Health , Oxford Respiratory National Institute For Health Research , Meso Scale Discovery , National Institute , Health Research Biomedical Centre , Model Mech , Rev Immunol , Opin Pulm Med , Rev Respir Med , Characterisation Protocol United , Respir Med ,

Burn More Fat With EVOO Get Ripped Superfood: Olive Oil

Burn More Fat With EVOO Get Ripped Superfood: Olive Oil
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Saudi Arabia , United States , Daniel Gwartney , Gerontol Geriatr , Nutr Biochem , J Vitam Nutr , J Clin Nutr , Many Health , Olive Oil , Uc Davis Olive Center , Pomace Oil , United States Department Of Agriculture , Ripped Superfood , Northern European , United States Standards , Olive Pomace Oil , Reduced Insulin , States Department , Intern Med , Res Rev , Pharm Des , Nutr Sci Vitaminol , Model Mech , Pacj Clin Nutr , Lipid Res , Biol Chem ,