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Efficacy of psilocybin for treating symptoms of depression: systematic review and meta-analysis

Objective To determine the efficacy of psilocybin as an antidepressant compared with placebo or non-psychoactive drugs.

Design Systematic review and meta-analysis.

Data sources Five electronic databases of published literature (Cochrane Central Register of Controlled Trials, Medline, Embase, Science Citation Index and Conference Proceedings Citation Index, and PsycInfo) and four databases of unpublished and international literature (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, ProQuest Dissertations and Theses Global, and PsycEXTRA), and handsearching of reference lists, conference proceedings, and abstracts.

Data synthesis and study quality Information on potential treatment effect moderators was extracted, including depression type (primary or secondary), previous use of psychedelics, psilocybin dosage, type of outcome measure (clinician rated or self-reported), and personal characteristics (eg, age, sex). Data were synthesised using a ....

Mike Clarke , Marina Metaxa , University Of Oxford Nuffield Department Medicine , Department For Continuing Education , International Prospective Register Of Systematic , International Clinical Trials Registry Platform , University Of Oxford Msc , Athina Marina Metaxa , Am Metaxa , Cochrane Central Register , Controlled Trials , Science Citation Index , Conference Proceedings Citation Index , Clinical Trials Registry Platform , Proquest Dissertations , Theses Global , International Prospective Register , Systematic Reviews , Cochrane Handbook , Oxford Nuffield Department , Primary Care Health Sciences , Continuing Education , Open Access , Creative Commons Attribution Non Commercial ,

"Exploring approaches to contemporary clinical incident analysis method" by Kathryn Kynoch, Xianliang Liu et al.

Objective: This review will explore the literature on contemporary incident analysis methods used in acute hospital settings, identifying types and characteristics of these methods and how they are used to minimize, prevent, or learn from errors and improve patient safety. Introduction: Safety is a major focus in health care; however, despite best efforts, errors and incidents still occur, leading to harm or potential harm to patients, families, carers, staff, or the organization. Incident analysis methods aim to reduce risk of harm. Traditional methods have been criticized for failing to consider the complexity of health care and the dynamic nature of acute care settings. Alternative methodologies are being sought to achieve higher levels of patient safety and care quality care in hospitals. Learning from errors and communicating with those involved in incidents are key requirements in contemporary incident analysis. Inclusion criteria: This review will consider empirical research pub ....

Cochrane Library , Proquest Dissertations , Clinical Incident Analysis , Hazard Analysis , Patient Safety , Scoping Review ,

"Older persons' perceptions and experiences of community palliative car" by Antoinette Cotton, Jan Sayers et al.

OBJECTIVE: The objective of this review was to critically appraise and synthesize qualitative evidence of older persons' perceptions and experiences of community palliative care. INTRODUCTION: Palliative care focuses on the relief of symptoms and suffering at the end of life and is needed by approximately 56.8 million people globally each year. An increase in aging populations coupled with the desire to die at home highlights the growing demand for community palliative care. This review provides an understanding of the unique experiences and perceptions of older adults receiving community palliative care. INCLUSION CRITERIA: This review appraised qualitative studies examining the perceptions and experiences of older adults (65 years or older) receiving community palliative care. Eligible research designs included, but were not limited to, ethnography, grounded theory, and phenomenology. METHODS: A search of the literature across CINAHL (EBSCOhost), MEDLINE (Ovid), Embase (Ovid SP) ....

Science Core Collection , Proquest Dissertations ,

Autism intervention meta-analysis of early childhood studies (Project AIM): updated systematic review and secondary analysis

Objective To summarize the breadth and quality of evidence supporting commonly recommended early childhood autism interventions and their estimated effects on developmental outcomes.

Design Updated systematic review and meta-analysis (autism intervention meta-analysis; Project AIM).

Data sources A search was conducted in November 2021 (updating a search done in November 2017) of the following databases and registers: Academic Search Complete, CINAHL Plus with full text, Education Source, Educational Administration Abstracts, ERIC, Medline, ProQuest Dissertations and Theses, PsycINFO, Psychology and Behavioral Sciences Collection, and SocINDEX with full text, Trials , and ClinicalTrials.gov.

Eligibility criteria for selecting studies Any controlled group study testing the effects of any non-pharmacological intervention on any outcome in young autistic children younger than 8 years.

Review methods Newly identified studies were integrated into the previous data ....

United States , Argyll And Bute , United Kingdom , New Jersey , Suzanne Albarran , Shannon Crowley Lapoint , Kristen Bottema Beutel , Kacie Dunham , Nicolette Caldwell , D Jonah Barrett , Jacobi Feldman , Tiffany Woynaroski , National Institutes Of Health , Jersey Autism Center , National Disability Insurance Scheme Of Australia , Vanderbilt Institute For Clinical , National Center , Behavioral Sciences Collection , National Institute For Health , Department Of Hearing , Human Services , Educational Administration Abstracts , Interagency Autism Coordinating Committee , Arkansas Association For Behavior Analysis , Translational Research , Us Department Of Health ,