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Researchers from across Oxford's Medical Sciences and Mathematical, Physical and Life Sciences Divisions have contributed to a new report on the future of healthcare, compiled by Citi Global Perspectives & Solutions (Citi GPS).
Objective To determine the efficacy of psilocybin as an antidepressant compared with placebo or non-psychoactive drugs.
Design Systematic review and meta-analysis.
Data sources Five electronic databases of published literature (Cochrane Central Register of Controlled Trials, Medline, Embase, Science Citation Index and Conference Proceedings Citation Index, and PsycInfo) and four databases of unpublished and international literature (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, ProQuest Dissertations and Theses Global, and PsycEXTRA), and handsearching of reference lists, conference proceedings, and abstracts.
Data synthesis and study quality Information on potential treatment effect moderators was extracted, including depression type (primary or secondary), previous use of psychedelics, psilocybin dosage, type of outcome measure (clinician rated or self-reported), and personal characteristics (eg, age, sex). Data were synthesised using a random effects me