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Efficacy of psilocybin for treating symptoms of depression: systematic review and meta-analysis

Objective To determine the efficacy of psilocybin as an antidepressant compared with placebo or non-psychoactive drugs.

Design Systematic review and meta-analysis.

Data sources Five electronic databases of published literature (Cochrane Central Register of Controlled Trials, Medline, Embase, Science Citation Index and Conference Proceedings Citation Index, and PsycInfo) and four databases of unpublished and international literature (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, ProQuest Dissertations and Theses Global, and PsycEXTRA), and handsearching of reference lists, conference proceedings, and abstracts.

Data synthesis and study quality Information on potential treatment effect moderators was extracted, including depression type (primary or secondary), previous use of psychedelics, psilocybin dosage, type of outcome measure (clinician rated or self-reported), and personal characteristics (eg, age, sex). Data were synthesised using a ....

Mike Clarke , Marina Metaxa , University Of Oxford Nuffield Department Medicine , Department For Continuing Education , International Prospective Register Of Systematic , International Clinical Trials Registry Platform , University Of Oxford Msc , Athina Marina Metaxa , Am Metaxa , Cochrane Central Register , Controlled Trials , Science Citation Index , Conference Proceedings Citation Index , Clinical Trials Registry Platform , Proquest Dissertations , Theses Global , International Prospective Register , Systematic Reviews , Cochrane Handbook , Oxford Nuffield Department , Primary Care Health Sciences , Continuing Education , Open Access , Creative Commons Attribution Non Commercial ,

'On par with the biggest breakthroughs in medicine': Spokane doctor discovers new kidney disease treatment. An 11,000-person study will start in 2024

'On par with the biggest breakthroughs in medicine': Spokane doctor discovers new kidney disease treatment. An 11,000-person study will start in 2024
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