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New drug candidate reverses obesity in mice by transforming liver metabolism

A mitochondrial transcription inhibitor (IMT) shifted metabolism in high-fat diet mice toward fatty acid oxidation, leading to weight loss, reduced liver fat, and improved glucose tolerance. ....

Lab Animal Monitoring System , Nature Metabolism , Comprehensive Lab Animal Monitoring System , Taolin Yuan , Postdoctoral Researcher , Professor Nils G , Principal Investigator , Weight Loss ,

Study reveals molecular changes in 19 organs due to exercise

The health benefits of exercise are well known but new research shows that the body's response to exercise is more complex and far-reaching than previously thought. ....

United States , Robert Gerszten , Steve Carr , Natalie Clark , Julian Avila , Christopher Newgard , Hasmik Keshishian , Pierre Jean Beltran , Clary Clish , David Amar , Courtney Dennis , Carver College Of Medicine , Broad Institute , Duke University , National Institutes Of Health , Molecular Transducers Of Physical Activity Consortium Motr , Beth Israel Deaconess Medical Center , Stanford University , University Of Iowa , Molecular Transducers , Physical Activity Consortium , National Institutes , Proteomics Platform , Metabolomics Platform , Nicole Gay , Sue Bodine ,

Therapeutic potential of human umbilical cord-derived mesenchymal stem cells in Crohn's disease

Whether human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) could heal luminal ulcers in Crohn’s disease. ....

Lobachad Shutterstok , Kyoto Encyclopedia , Crohns Disease , Mesenchymal Stem Cells , Stem Cells , Umbilical Cord ,

Scripps Research scientists uncover plausible pathway for protocell formation

Roughly 4 billion years ago, Earth was developing conditions suitable for life. Origin-of-life scientists often wonder if the type of chemistry found on the early Earth was similar to what life requires today. ....

Ashok Deniz , Ramanarayanan Krishnamurthy , Sunil Pulletikurti , Scripps Research Institute , Department Of Chemistry At Scripps Research , Computational Biology At Scripps Research , Department Of Integrative Structural , Scripps Research , Integrative Structural , Computational Biology , Fatty Acids ,

Simple blood test to detect Alzheimer's disease may replace more invasive diagnostic methods

A simple blood test to diagnose Alzheimer's disease soon may replace more invasive and expensive screening methods such as spinal taps and brain scans. ....

Suzanne Schindler , Gemma Salvad , Oskar Hansson , Randallj Bateman , Nicolas Barth , Washington University Charles , Washington University , Drug Administration , Washington University School Of Medicine , Joanne Knight Alzheimer Disease Research Center , Lund University , University School , Washington University School , Joanne Knight Distinguished Professor , Blood Test , Lzheimer 39s Disease ,