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Partners of 1.3 million EUR research project on Alzheimer's disease meet for General Assembly in Tel Aviv, Israel

Partners of 1.3 million EUR research project on Alzheimer's disease meet for General Assembly in Tel Aviv, Israel
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Tel Aviv , Ha Afon , Dead Sea , Israel General , Recerca Biom , Sophia Krix Fraunhofer , Valle Fundaci , National Research Fund , European Working Group Of People , Aviv Medical Center , Uri Nevo University Of Tel Aviv , Ministry Of Health , Neurodegenerative Disease Research , Michal Schwartz Weizmann Institute Of Science , Eu Joint Programme , Assembly In Tel Aviv , National Research , Innovation Office , National Institute Of Health Carlos , Ministry Of Education , General Assembly , Immune Profiling , Cytotoxic Lymphocytes , Uri Nevo , Vanessa Lage Rupprecht , Christophe Bintener ,

CNIO researchers help to decipher the structure of the large molecular machine that activates mTOR

CNIO researchers help to decipher the structure of the large molecular machine that activates mTOR
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Mohinder Pal , Laurenceh Pearl , Chrisostomos Prodromou , European Regional Development Fund , Damage Response Group , Spanish Ministry Of Science , Community Of Madrid , Sciences Research Council , Spanish National Cancer Research Centre , Stability Centre , University Of Sussex United Kingdom , National Institute Of Health Carlos , Cell Reports , Genome Damage , United Kingdom , Structural Biology , Macromolecular Complexes , Response Group , Spanish Ministry , National Institute , Health Carlos , Welcome Trust , Biological Sciences Research Council , மொிந்தேர் நண்பா , ஐரோப்பிய பிராந்திய வளர்ச்சி நிதி , சேதம் பதில் குழு ,

CNIO researchers discover that a protein that facilitates DNA repair may potentiate chemotherapy

CNIO researchers discover that a protein that facilitates DNA repair may potentiate chemotherapy
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United States , Luis Blanco , Selena Blanco , Massimo Lopes , Severo Ochoa , Patricia Ubieto , Daniel Gonz , European Regional Development Fund , Spanish Ministry Of Science , Replication Group , University Of Zurich Switzerland , Experimental Therapeutics Programme , Washington University St Louis , Swiss National Science Foundation , European Research Council , National Institute Of Health Carlos , Centro De Biolog , Molecular Severo Ochoa , Washington University , Therapeutics Programme , Score Unit , Spanish Ministry , National Institute , Health Carlos , European Research , ஒன்றுபட்டது மாநிலங்களில் ,

A connection between senescence and stem cells caused by a breast cancer-initiating protein

Researchers from the Spanish National Cancer Research Centre (CNIO) and the IDIBELL, led by Eva González-Suárez at the CNIO, have found that the hyperactivation of the RANK pathway plays a double function in breast cells: in the early stages of cancer, it activates senescence, which has a protective effect and delays the appearance of tumours; in more advanced stages, RANK-induced senescence favours the accumulation of stem cells, which promotes tumour growth and aggressiveness. ....

Eva Gonz , European Regional Development Fund , Spanish National Cancer Research Centre , Bellvitge Biomedical Research Institute , Spanish Ministry Of Science , European Research Council , National Institute Of Health Carlos , Developmental Cell , Spanish Ministry , National Institute , Health Carlos , Molecular Biology , Breast Cancer , Clinical Trials , Health Professionals , Disease In The Developing World , ஈவா கோன்ஸ் , ஐரோப்பிய பிராந்திய வளர்ச்சி நிதி , ஸ்பானிஷ் தேசிய புற்றுநோய் ஆராய்ச்சி மையம் , ஸ்பானிஷ் அமைச்சகம் ஆஃப் அறிவியல் , ஐரோப்பிய ஆராய்ச்சி சபை , தேசிய நிறுவனம் ஆஃப் ஆரோக்கியம் கார்லோஸ் , வளர்ச்சி செல் , ஸ்பானிஷ் அமைச்சகம் , தேசிய நிறுவனம் , ஆரோக்கியம் கார்லோஸ் ,

CNIO researchers discover the cause of neuronal death in a large proportion of familial ALS patients

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IMAGE: Mouse motor neurons, generated from mouse embryonic stem cells exposed (right) or not (left) to ALS-associated peptides (right). As observed in patients, these peptides are toxic and cause neuronal death..
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Credit: CNIO
In Amyotrophic Lateral Sclerosis (ALS), the progressive death of neurons that control body movement leads to paralysis of muscles in the limbs and gradually of the whole body, which ultimately makes it impossible to breathe. ALS is currently untreatable, and its cause is unknown.
It is known, however, that in 10% of affected individuals there is a strong genetic component, which causes the disease to occur in several members of a single family. In about half of these cases of familial ALS, the origin lies in a gene called C9ORF72. But why do mutations in this gene kill motor neurons? ....

Oleksandra Sirozh , Deutsche Forschungsgemeinschaft , Jack Szostak , Vanesa Lafarga , Spanish National Cancer Research Centre , Genomic Instability Group , Spanish Ministry Of Science , European Research Council , National Institute Of Health Carlos , Banco Santander , Amyotrophic Lateral Sclerosis , Spanish Ministry , National Institute , Health Carlos , Santander Universities , Biomedical Environmental Chemical Engineering , Cell Biology , Medicine Health , பலா ஸ்ஜோஸ்த்தக் , ஸ்பானிஷ் தேசிய புற்றுநோய் ஆராய்ச்சி மையம் , ஸ்பானிஷ் அமைச்சகம் ஆஃப் அறிவியல் , ஐரோப்பிய ஆராய்ச்சி சபை , தேசிய நிறுவனம் ஆஃப் ஆரோக்கியம் கார்லோஸ் , பான்கோ சாந்தண்டர் , ஸ்பானிஷ் அமைச்சகம் , தேசிய நிறுவனம் ,