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Researchers from the Spanish National Cancer Research Centre (CNIO) and the IDIBELL, led by Eva González-Suárez at the CNIO, have found that the hyperactivation of the RANK pathway plays a double function in breast cells: in the early stages of cancer, it activates senescence, which has a protective effect and delays the appearance of tumours; in more advanced stages, RANK-induced senescence favours the accumulation of stem cells, which promotes tumour growth and aggressiveness. ....
They followed in the footsteps of their father, grandfather and great-grandfather Their father was Paquirri, who was gored to death by a bull in 1984 The brothers are locked in a public feud with their stepmother over heirlooms. Brothers from Spain s most celebrated celebrated bullfighting dynasty whose matador father was gored to death are locked in a public feud with their stepmother over priceless family heirlooms. Francisco Rivera Ordóñez, 46 and his brother Cayetano, 43, are fourth-generation bullfighters who married into aristocracy, mingle with celebrities and are as popular in Spain as film stars and footballers , explained AirMail s Patrick Kidd. ADVERTISEMENT In a case that has gripped Spain, the brothers have accused their stepmother Isabel Pantoja, 64, a famous singer and talent show judge, of withholding their inheritance, namely the capes, swords and traje de luces, or bullfighter’s suit of lights , used by their father in the ri ....
Osteoporosis drug also promotes infiltration of immune cells in breast tumors The team of Eva González-Suarez, from the CNIO and IDIBELL, and the team of Christos Sotiriou, from the Jules Bordet Institute, demonstrate that a drug already used to treat osteoporosis promotes the infiltration of immune cells in breast tumors These findings propose a new target to increase the antitumor immune response and make breast cancer more sensitive to immunotherapy Despite the success of immunotherapy in the treatment of cancers such as lung or melanoma, it is still not effective in breast cancers for being cold , with low infiltration of immune cells. ....