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E-Mail Dimerization (Note: combination of two identical or different molecules) of the human neuropeptides oxytocin and vasopressin can produce new types of bioactive molecules. In a recent study, an international research team led by MedUni Vienna and the University of Vienna demonstrated that dimerized and therefore significantly larger versions of oxytocin and vasopressin are still able to activate their receptors. Such new constructs provide several opportunities to optimize the efficacy of these neuropeptides for therapeutic application. The researchers were inspired for this approach from naturally occurring dimers. The results have been published in the journal Chemical Science . Oxytocin/vasopressin receptors are typical examples of so-called G protein-coupled receptors - the most successful drug target class. The oxytocin and vasopressin receptors are targeted, for example, during childbirth to encourage contractions but are also being investigated for the ....
Date Time Therapeutic potential of peptides Currently there are more than 80 peptide drugs on the global market and about twice as many in clinical development. Due to their beneficial properties, these biomolecules play already an important role in the treatment of diseases such as diabetes, cancer, hormone disorders, HIV infection, and multiple sclerosis. In the recent issue of “Nature Reviews Drug Discovery”, a team of Austrian and Australian scientists led by medicinal chemist Markus Muttenthaler of the University of Vienna present an outlook on the latest trends in peptide drug discovery and development. “Insulin is a prime example for a successful peptide drug that has been essential for the health of millions of diabetic patients in the past 100 years,” says Markus Muttenthaler, who leads research groups at the Institute of Biological Chemistry of the Faculty of Chemistry at University in Vienna as well as at the Institute for Molecular Bioscience, at th ....