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Snake-Venom 'Super Glue' Can Stop Wounds Bleeding in Seconds With a Flash of Light


Venom s usually the stuff of nightmares. Animals that wield it send instinctive shivers down our spines.
But scientists are teasing out useful purposes for these powerful substances that (sometimes incidentally) can cause us so much pain and damage. Recently we ve seen developments from several types of venoms, from bee venom as a cancer treatment to using platypus venom for diabetes.
 
A team of researchers has developed the next venom-based medical advancement: a fast-acting super glue that stops bleeding in under a minute.
While synthetic adhesives can be easier to manipulate, their degradation can potentially be toxic. Meanwhile, natural bioadhesives are more likely to have excellent biocompatibility , explained the authors in their new paper, but limited overall integrity and adhesion. ....

United States , Markus Muttenthaler , Peter Macdonald , Kibret Mequanint , Victor Chang Cardiac Research Institute , University Of Vienna , South America , Western University , Fraser Island , Victor Chang Cardiac Research , ஒன்றுபட்டது மாநிலங்களில் , பீட்டர் மெக்டொனால்ட் , வெற்றியாளர் சாங் இதய ஆராய்ச்சி நிறுவனம் , பல்கலைக்கழகம் ஆஃப் வியன்னா , தெற்கு அமெரிக்கா , மேற்கு பல்கலைக்கழகம் , ஃப்ரேசர் தீவு , வெற்றியாளர் சாங் இதய ஆராய்ச்சி ,

Dimerized Neuropeptide Discovery inspired by Nature


Mar 12 2021 Read 412 Times
In a recent study led by MedUni Vienna and the University of Vienna, researchers demonstrated that dimerized (a combination of two identical or different molecules) and therefore significantly larger versions of human neuropeptides oxytocin and vasopressin are still able to activate their receptors without forfeiting too much of their efficacy. Such new constructs provide several opportunities to optimise the efficacy of these neuropeptides for therapeutic application.
Oxytocin/vasopressin receptors are typical examples of so-called G protein-coupled receptors – the most successful drug target class, which are being investigated for therapeutic applications in cardiovascular disease, cancer and developmental disorders such as autism. ....

Roland Hellinger , Christianw Gruber , Christian Bergmayr , Huang Xiang , Christian Gruber , Ngari Teakle , Dennis Kurzbach , Dalia Gharib , Thomas Kremsmayr , Zoltan Dekan , Peter Keov , Fernando Albericio , Mathilde Godin , Markus Muttenthaler , Marta Vilaseca , Paulf Alewood , Institute Of Pharmacology Meuni Vienna , University Of Vienna , Meduni Vienna , Pharmacology Meuni Vienna , Biological Chemistry , Marina Gay , Chemical Science , ரோலண்ட் நரகத்தில் , ஹுவாங் கிஷியாங் , கிறிஸ்துவர் க்ரூபர் ,

Scientists present new outlook on latest trends in peptide drug discovery and development


Scientists present new outlook on latest trends in peptide drug discovery and development
Currently there are more than 80 peptide drugs on the global market and about twice as many in clinical development. Due to their beneficial properties, these biomolecules play already an important role in the treatment of diseases such as diabetes, cancer, hormone disorders, HIV infection, and multiple sclerosis.
In the recent issue of
Nature Reviews Drug Discovery , a team of Austrian and Australian scientists led by medicinal chemist Markus Muttenthaler of the University of Vienna present an outlook on the latest trends in peptide drug discovery and development. ....

Markus Muttenthaler , Christophe Duplai , Paulf Alewood , Emily Henderson , Institute For Molecular Bioscience , University Of Queensland , University Of Vienna , Reviews Drug , Biological Chemistry , Molecular Bioscience , Nobel Prize , French Guyana , Medicinal Chemist , Drug Discovery , Lion Channel , எமிலி ஹென்டர்சன் , நிறுவனம் க்கு மூலக்கூறு உயிர் அறிவியல் , பல்கலைக்கழகம் ஆஃப் குயின்ஸ்லாந்து , பல்கலைக்கழகம் ஆஃப் வியன்னா , மதிப்புரைகள் மருந்து , உயிரியல் வேதியியல் , மூலக்கூறு உயிர் அறிவியல் , நோபல் ப்ரைஸ் , பிரஞ்சு கையந , மருத்துவ வேதியியலாளர் , மருந்து கண்டுபிடிப்பு ,