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Vaccine boosts innate immunity in people with

<p><strong>Bacillus Calmette-Gu&eacute;rin (BCG) is one of the world&rsquo;s oldest and most widely used vaccines. It was developed in the early 20<sup>th</sup> century to provide protection from tuberculosis. Surprisingly, this vaccine protects not only against tuberculosis but also reduces the risk for various other infections, through a mechanism called trained immunity. A new study led by Christoph Bock and Mihai Netea found that epigenetic cell states predict whether or not an individual profits from the &ldquo;wake-up call&rdquo; to the innate immune system that is provided by the BCG vaccine. This discovery contributes to the development of future therapeutics that induce protective trained immunity.</strong></p>
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United States , Christoph Bock , Erwin Schr , Mihai Netea , Stefan Bernhardt , Netherlands Royal Academy Of Sciences , Cemm Research Center , University Of Vienna , Christoph Bock Cemm Medical University Of Vienna , Radboud University Medical Center , European Research Council , Mihai Netea Radboud University Medical Center , Department Of Internal Medicine , Prize Of The Austrian Academy Sciences , Research Center , Austrian Academy Of Sciences , European Union Horizon , European Lab For , Infectious Diseases Society Of America , Netherlands Organization For Scientific Research , Austrian Science Fund Special Research Area , Human Cell Atlas Organizing Committee , Method Of Research , Pr Communications , Curie Actions Individual Fellowship , European Union ,

New method enabling therapeutical targeting o

Scientists from the Giulio Superti-Furga Lab at CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, have developed a new method that allows the discovery of specific inhibitors of a lactate transporter associated with cancer and other disease areas. The compound identified in the assay system could provide a new starting point for cancer treatments. The study has now been published in Cell Chemical Biology. ....

Baden Wüberg , Vojtech Dvorak , University Of Vienna Meduni , University Of Vienna , Giulio Superti Furga Lab At Ce , Cemm Research Center , Research Center , University Of Zurich , Innovative Medicine Initiative , European Research Council , Giulio Superti Furga Lab , Molecular Medicine , Austrian Academy , Cell Chemical , Giulio Superti Furga , Scientific Director , Medical University , Cell Chemical Biology , Medical Systems Biology , Vienna General , Meduni Vienna , Uni Vienna ,