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Light show in living cells

<p>Observing proteins precisely within cells is extremely important for many branches of research but has been a significant technical challenge - especially in living cells, as the required fluorescent labelling had to be individually attached to each protein. The research group led by Stefan Kubicek at CeMM has now overcome this hurdle: With a method called &quot;vpCells,&quot; it is possible to label many proteins simultaneously, using five different fluorescent colours. This automated high-throughput approach, aided by AI-assisted image recognition, opens up entirely new applications in various disciplines, from fundamental cell biology to drug discovery. The study has been published in the journal <em>Nature Cell Biology</em> (DOI: 10.1038/s41556-024-01407-w), and the related images are available at <em>vpcells.cemm.at</em>.</p>
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Stuart Schreiber , Maria Ciobanu , Marton Siklos , Viktoriia Kartysh , Tatjana Tomek , Stefan Kubicek , Thomas Jenuwein , Anna Koren , Stefan Bernhardt , Andreas Reicher , Monika Malik , European Union Horizon , Method Of Research , Boehringer Ingelheim , Austrian Science Fund , Technology Fund , Research Center , Broad Institute Of Harvard , European Research Council , Vienna University Of Technology , Pr Communications , Cemm Research Center , Molecular Medicineof The Austrian Academy Of Sciences , Austrian Academy Of Sciences , Christian Doppler Laboratory For Chemical Epigenetics , Nature Cell Biology ,

Systematic review: The involvement of bitter taste receptors in cancer

Humans have 25 different types of functional bitter taste receptors. These are found on our tongue, where they facilitate the taste perception of bitter tasting compounds. In addition, there are increasing findings that cells of extra-oral organs also have such receptors. ....

Agnes Mistlberger Reiner , Veronika Somoza , Emily Henderson , Technical University Of Munich , Leibniz Institute In Freising , Technology Fund , Department Of Physiological Chemistry , Leibniz Institute For Food Systems Biology , University Of Vienna , Physiological Chemistry , Leibniz Institute , Food Systems Biology , Technical University , Medical University , Vienna Science ,