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Study opens a window of opportunity to design RAF1 degraders against lung adenocarcinomas

One of the main challenges in oncology is the development of drugs against KRAS oncogenes. These oncogenes -genes that cause cancer when mutated - are responsible for a quarter of all human cancers, including the three tumor types with the highest mortality rates: lung adenocarcinoma, colorectal carcinoma and pancreatic ductal adenocarcinoma. ....

Pablo Mesa , Mariano Barbacid , Sara Garc , Emily Henderson , University Of Copenhagen , Molecular Cell , Structural Biology ,

Key step in development of new drugs against lung cancer

Key step in development of new drugs against lung cancer
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Pablo Mesa , Mariano Barbacid , Sara Garc , University Of Copenhagen , Spanish Association Against Cancer , Spanish Ministry Of Science , Cancer Foundation , European Research Council , Research Fund , Molecular Cell , Structural Biology , Spanish Ministry ,