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Study elucidates the role of two isoforms of KRAS oncogenes


Study elucidates the role of two isoforms of KRAS oncogenes
KRAS was one of the first oncogenes to be identified, a few decades ago. It is among the most common drivers of cancer and its mutations can be detected in around 25 per cent of human tumors. The development of KRAS inhibitors is, thus, an extremely active line of research. Effective results have been elusive so far, though - no KRAS inhibitor had been available until a month ago, when the FDA granted approval to Sotorasib.
KRAS encodes two gene products, KRAS4A and KRAS4B, whose levels can vary across organs and embryonic stages. When KRAS mutates, both variants, or isoforms, are activated. Though, some studies have focussed on approaches to target only KRAS4B, since it usually found to be expressed at higher levels in tumors. ....

Mariano Barbacid , Eduardo Caleiras , Marina Salm , Matthias Drosten , Sagrario Ortega , Guillem Paniagua , Emily Henderson , Autonomous Community Of Madrid , Institute Of Health Carlos , Experimental Oncology Group , Spanish Ministry Of Science , European Research Council , Research Fund , Experimental Oncology Programme , Oncology Group , Mouse Genomic Editing Core Unit , Score Unit , Histopathology Core Unit , Spanish Ministry , Health Carlos , Autonomous Community , எமிலி ஹென்டர்சன் , தன்னாட்சி சமூக ஆஃப் மாட்ரிட் , நிறுவனம் ஆஃப் ஆரோக்கியம் கார்லோஸ் , சோதனை புற்றுநோயியல் குழு , ஸ்பானிஷ் அமைச்சகம் ஆஃப் அறிவியல் ,

CNIO researchers clarify role of two isoforms of KRAS, most common oncogene in humans

CNIO researchers clarify role of two isoforms of KRAS, most common oncogene in humans
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Mariano Barbacid , Marina Salm , Matthias Drosten , Guillem Paniagua , Experimental Oncology Group , Experimental Oncology Programme , Oncology Group , சோதனை புற்றுநோயியல் குழு , புற்றுநோயியல் குழு ,

Xosé Bustelo recibirá el premio Ramiro Carregal


Xosé Bustelo recibirá el premio Ramiro Carregal
El doctor Xosé Ramón García Bustelo, que recogerá el IX Premio Internacional, en una foto de archivo.
Foto: EFE
El próximo 9 de septiembre tendrá lugar en el Hostal dos Reis Católicos de Santiago la gala de entrega de los Premios de Investigación Oncológica, Científica y Técnica Ramiro Carregal que la pandemia obligó a retrasar durante más de un año. En el acto, el doctor Xosé Ramón García Bustelo recogerá el IX Premio Internacional y César Serrano el II Premio Talentos Emergentes en Investigación Oncológica. Ambos estarán presentes en la entrega que se celebrará con todas las medidas de prevención necesarias para llevar a cabo el acto con seguridad. ....

Mariano Barbacid , Caesar Serrano , Ramiro Carregal , Raphael Silva , Research Has , University Hospital Vall , Reis Catholic Santiago , Technical Ramiro Carregal , Ninth International , Ana Lluch , Prize Ramiro , Thus Was , Doctor Caesar Serrano , Institute Of Pre , Oncology Vall , New Edition , Society Of Medical Oncology Spaniard , ரபேல் சில்வா , ஆராய்ச்சி உள்ளது , பல்கலைக்கழகம் மருத்துவமனை வால் , ஒன்பதாவது சர்வதேச , நிறுவனம் ஆஃப் பிரே , புதியது பதிப்பு ,