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Protein Modifications Influence Neurodegenerative Diseases miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.
Protein modifications key influencers in neurodegenerative diseases sciencedaily.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencedaily.com Daily Mail and Mail on Sunday newspapers.
Neurodegenerative diseases, such as Alzheimer's and Parkinson's, present a significant health challenge, affecting over 50 million people globally. ....
January 21, 2021 The protein transthyretin (TTR) may play a role in the development of new treatments for Alzheimer’s disease by preventing the formation of amyloid beta clumps, according to a study published in the Journal of Biological Chemistry. Found in amyloid beta clumps, TTR has previously demonstrated an apparent protective effect against the development of Alzheimer’s disease. Mouse studies have shown that animals with more TTR are slower to develop Alzheimer’s-like symptoms, while those with less TTR develop the condition more quickly, researchers explained CREDIT: UT Southwestern Medical Center The new research discovery involves what researchers consider opposing functions of TTR. In healthy individuals, TTR forms a tetramer, a clover-resembling shape with 4 identical leaflets, to help transport thyroid hormone and the vitamin A derivative retinol throughout the body. But when the protein separates into molecules called monomers, TTR can f ....
Read Time: A protein that wreaks havoc in the nerves and heart when it clumps together can prevent the formation of toxic protein clumps associated with Alzheimerâs disease, a new study led by a UT Southwestern researcher shows. The findings, published recently in the Journal of Biological Chemistry, could lead to new treatments for this brain-ravaging condition, which currently has no truly effective therapies and no cure. Researchers have long known that sticky plaques of a protein known as amyloid beta are a hallmark of Alzheimerâs and are toxic to brain cells. As early as the mid-1990s, other proteins were discovered in these plaques as well. ....